Gao Lihong, Shi Yali, Li Wenhui, Liu Jiemin, Cai Yaqi
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
J Environ Monit. 2012 Apr;14(4):1248-55. doi: 10.1039/c2em10916f. Epub 2012 Mar 9.
The occurrence, distribution and bioaccumulation of 22 antibiotics, including eight fluoroquinolones (FQs), nine sulfonamides (SAs) and five macrolides (MLs), in the Haihe River were investigated. Surface water, sediment and fish samples were analyzed by HPLC-MS/MS. Ofloxacin, sulfamethoxazole, sulfadiazine, erythromycin and roxithromycin were found in all surface water samples. SAs were the predominant antibiotics in surface water samples in the mainstream of Haihe River, with the maximum concentration of 201 ng L(-1) for sulfamethoxazole. Compared with Haihe River, higher concentrations of antibiotics were found in the surface water samples in the Dagu and Chentaizi Drainage Rivers. The antibiotics pollution in the mainstream of Haihe River may derive from its tributaries, whereas the wastewater from fish ponds was not the main source of FQs, SAs and MLs in the river water. In sediment samples, FQs were the most frequently detected antibiotics and their concentrations were much higher than SAs and MLs. The high concentrations and detection frequencies of FQs in sediments indicate that sediments are an important reservoir for FQs as they are strongly adsorbed onto sediments. Ciprofloxacin and erythromycin exhibited potential bioaccumulation in crucian carp, with mean bioaccumulation factors of 3262 L kg(-1) and 4492 L kg(-1), respectively.
对海河中包括8种氟喹诺酮类（FQs）、9种磺胺类（SAs）和5种大环内酯类（MLs）在内的22种抗生素的发生、分布和生物累积情况进行了调查。采用高效液相色谱-串联质谱法（HPLC-MS/MS）对地表水、沉积物和鱼类样本进行了分析。在所有地表水样本中均检测到了氧氟沙星、磺胺甲恶唑、磺胺嘧啶、红霉素和罗红霉素。磺胺类是海河干流地表水样本中的主要抗生素，磺胺甲恶唑的最大浓度为201 ng L⁻¹。与海河相比，大沽河和陈台子排水河中地表水样本中的抗生素浓度更高。海河干流的抗生素污染可能源自其支流，而鱼塘废水并非河水氟喹诺酮类、磺胺类和大环内酯类的主要来源。在沉积物样本中，氟喹诺酮类是最常检测到的抗生素，其浓度远高于磺胺类和大环内酯类。沉积物中氟喹诺酮类的高浓度和高检出频率表明，沉积物是氟喹诺酮类的重要储存库，因为它们会强烈吸附在沉积物上。环丙沙星和红霉素在鲫鱼中表现出潜在的生物累积性，平均生物累积因子分别为3262 L kg⁻¹和4492 L kg⁻¹。
