ter Meulen J, Wittkowski K M, Kidenya J J, Pöllath M, Dörries R, Fleischer K, Dietz K, ter Meulen V
Institut für Virologie und Immunbiologie, Universität Würzburg.
Eur J Epidemiol. 1989 Jun;5(2):158-63. doi: 10.1007/BF00156822.
To assess the possible role of sexually transmitted diseases as cofactors for the spread of AIDS, 248 adult patients were tested for the presence of antibodies against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and syphilis. The survey was conducted in a hospital at Kagondo, Kagera Region, Northwest Tanzania, Africa. Subjects were randomly chosen from the outpatient clinic to include those with and without sexually transmitted diseases, as well as AIDS/pre-AIDS patients. The data were univariately and multivariately analysed by linear logit models, including interactions of demographic parameters. The results obtained reveal a strong association between the presence of antibodies against HIV, syphilis and HBV, respectively. The HBV/HIV-correlation remained stable in the multivariate analysis including interactions of social parameters, in contrast to the syphilis/HIV-correlation. We assume that this reflects the lower virulence of HBV as compared to that of syphilis. The prevalence of anti-HBV antibodies seems to be a more reliable marker for high sexual activity than those against syphilis. The possibility that HBV and HIV act as cofactors for each other's transmission could not be ruled out.
为评估性传播疾病作为艾滋病传播辅助因素的潜在作用，对248名成年患者进行了针对人类免疫缺陷病毒（HIV）、乙型肝炎病毒（HBV）和梅毒抗体的检测。该调查在非洲坦桑尼亚西北部卡盖拉地区卡贡多的一家医院开展。研究对象从门诊随机选取，包括患有和未患有性传播疾病的患者以及艾滋病/艾滋病前期患者。数据通过线性对数单位模型进行单变量和多变量分析，包括人口统计学参数的交互作用。所得结果显示，针对HIV、梅毒和HBV的抗体之间分别存在强关联。与梅毒/HIV关联不同，在包括社会参数交互作用的多变量分析中，HBV/HIV相关性保持稳定。我们认为，这反映出与梅毒相比，HBV的毒力较低。抗HBV抗体的流行率似乎比抗梅毒抗体更能可靠地反映高性行为活跃度。不能排除HBV和HIV作为彼此传播辅助因素的可能性。
