超越 BOLD 之路：脑功能的分子影像学。
Is there a path beyond BOLD? Molecular imaging of brain function.
机构信息
Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Neuroimage. 2012 Aug 15;62(2):1208-15. doi: 10.1016/j.neuroimage.2012.02.076. Epub 2012 Mar 3.
Abstract
The dependence of BOLD on neuro-vascular coupling leaves it many biological steps removed from direct monitoring of neural function. MRI based approaches have been developed aimed at reporting more directly on brain function. These include: manganese enhanced MRI as a surrogate for calcium ion influx; agents responsive to calcium concentrations; approaches to measure membrane potential; agents to measure neurotransmitters; and strategies to measure gene expression. This work has led to clever design of molecular imaging tools and many contributions to studies of brain function in animal models. However, a robust approach that has potential to get MRI closer to neurons in the human brain has not yet emerged.
摘要
BOLD 对神经血管耦合的依赖性使其与神经功能的直接监测相差许多生物学步骤。已经开发了基于 MRI 的方法，旨在更直接地报告脑功能。这些方法包括：锰增强 MRI 作为钙离子内流的替代物；对钙浓度有反应的试剂；测量膜电位的方法；测量神经递质的试剂；以及测量基因表达的策略。这项工作导致了分子成像工具的巧妙设计，并为动物模型中的脑功能研究做出了许多贡献。然而，一种有潜力使 MRI 更接近人脑神经元的稳健方法尚未出现。
相似文献
1
Is there a path beyond BOLD? Molecular imaging of brain function.超越 BOLD 之路：脑功能的分子影像学。
Neuroimage. 2012 Aug 15;62(2):1208-15. doi: 10.1016/j.neuroimage.2012.02.076. Epub 2012 Mar 3.
2
Using manganese-enhanced MRI to understand BOLD.利用锰增强磁共振成像来理解 BOLD。
Neuroimage. 2012 Aug 15;62(2):1009-13. doi: 10.1016/j.neuroimage.2012.01.008. Epub 2012 Jan 8.
3
Quantitative functional MRI: concepts, issues and future challenges.定量功能磁共振成像：概念、问题及未来挑战。
Neuroimage. 2012 Aug 15;62(2):1234-40. doi: 10.1016/j.neuroimage.2011.10.046. Epub 2011 Oct 20.
4
The future of acquisition speed, coverage, sensitivity, and resolution.采集速度、覆盖范围、灵敏度和分辨率的未来。
Neuroimage. 2012 Aug 15;62(2):1221-9. doi: 10.1016/j.neuroimage.2012.02.077. Epub 2012 Mar 6.
5
Finding the BOLD effect in brain images.在脑影像中寻找 BOLD 效应。
Neuroimage. 2012 Aug 15;62(2):608-9. doi: 10.1016/j.neuroimage.2012.01.091. Epub 2012 Jan 28.
6
The future of functional MRI in clinical medicine.功能磁共振成像在临床医学中的未来。
Neuroimage. 2012 Aug 15;62(2):1267-71. doi: 10.1016/j.neuroimage.2012.01.026. Epub 2012 Jan 12.
7
The history and role of long duration stimulation in fMRI.长时程刺激在 fMRI 中的历史和作用。
Neuroimage. 2012 Aug 15;62(2):1051-5. doi: 10.1016/j.neuroimage.2012.01.045. Epub 2012 Jan 14.
8
The NIH experience in first advancing fMRI.NIH 在推动 fMRI 发展方面的经验。
Neuroimage. 2012 Aug 15;62(2):632-6. doi: 10.1016/j.neuroimage.2011.07.074. Epub 2011 Aug 9.
9
The future of susceptibility contrast for assessment of anatomy and function.评估解剖结构和功能的易感性对比的未来。
Neuroimage. 2012 Aug 15;62(2):1311-5. doi: 10.1016/j.neuroimage.2012.01.004. Epub 2012 Jan 8.
10
fMRI at 20: has it changed the world?20 世纪的 fMRI ：它改变了世界吗？
Neuroimage. 2012 Aug 15;62(2):1316-24. doi: 10.1016/j.neuroimage.2012.03.004. Epub 2012 Mar 10.
引用本文的文献
1
Preclinical Models for Cryptococcosis of the CNS and Their Characterization Using In Vivo Imaging Techniques.中枢神经系统隐球菌病的临床前模型及其使用体内成像技术的表征
J Fungi (Basel). 2024 Feb 12;10(2):146. doi: 10.3390/jof10020146.
2
Can MRI Be Used as a Sensor to Record Neural Activity?磁共振成像能否用作记录神经活动的传感器？
Sensors (Basel). 2023 Jan 25;23(3):1337. doi: 10.3390/s23031337.
3
Visualization of Brain Activity in a Neuropathic Pain Model Using Quantitative Activity-Dependent Manganese Magnetic Resonance Imaging.使用定量活动依赖性锰磁共振成像对神经病理性疼痛模型中的大脑活动进行可视化。
Front Neural Circuits. 2019 Nov 26;13:74. doi: 10.3389/fncir.2019.00074. eCollection 2019.
4
MRI Tracking of iPS Cells-Induced Neural Stem Cells in Traumatic Brain Injury Rats.MRI 示踪 iPS 细胞诱导的神经干细胞在创伤性脑损伤大鼠中的作用。
Cell Transplant. 2019 Jun;28(6):747-755. doi: 10.1177/0963689718819994. Epub 2018 Dec 21.
5
Next-generation probes, particles, and proteins for neural interfacing.用于神经接口的下一代探针、颗粒和蛋白质。
Sci Adv. 2017 Jun 9;3(6):e1601649. doi: 10.1126/sciadv.1601649. eCollection 2017 Jun.
6
Manganese-Enhanced Magnetic Resonance Imaging and Studies of Rat Behavior: Transient Motor Deficit in Skilled Reaching, Rears, and Activity in Rats After a Single Dose of MnCl.锰增强磁共振成像与大鼠行为研究：单次注射氯化锰后大鼠在熟练抓握、站立及活动方面的短暂运动缺陷
Magn Reson Insights. 2017 May 3;10:1178623X17706878. doi: 10.1177/1178623X17706878. eCollection 2017.
7
Manganese-Enhanced MRI: Biological Applications in Neuroscience.锰增强磁共振成像：在神经科学中的生物学应用
Front Neurol. 2015 Jul 10;6:161. doi: 10.3389/fneur.2015.00161. eCollection 2015.
8
Assessing recovery from neurodegeneration in spinocerebellar ataxia 1: Comparison of in vivo magnetic resonance spectroscopy with motor testing, gene expression and histology.评估脊髓小脑共济失调1型神经退行性变的恢复情况：体内磁共振波谱与运动测试、基因表达及组织学的比较
Neurobiol Dis. 2015 Feb;74:158-66. doi: 10.1016/j.nbd.2014.11.011. Epub 2014 Nov 29.
9
The movement of a nerve in a magnetic field: application to MRI Lorentz effect imaging.神经在磁场中的运动：在MRI洛伦兹效应成像中的应用。
Med Biol Eng Comput. 2014 May;52(5):491-8. doi: 10.1007/s11517-014-1153-y. Epub 2014 Apr 12.
10
Physical principles for scalable neural recording.可扩展神经记录的物理原理。
Front Comput Neurosci. 2013 Oct 21;7:137. doi: 10.3389/fncom.2013.00137. eCollection 2013.
本文引用的文献
1
Noninvasive detection of neural progenitor cells in living brains by MRI.通过 MRI 对活体大脑中的神经祖细胞进行无创检测。
FASEB J. 2012 Apr;26(4):1652-62. doi: 10.1096/fj.11-199547. Epub 2011 Dec 23.
2
Imaging and quantification of metastatic melanoma cells in lymph nodes with a ferritin MR reporter in living mice.在活体小鼠中使用铁蛋白磁共振报告基因对淋巴结中的转移性黑素瘤细胞进行成像和定量。
NMR Biomed. 2012 May;25(5):737-45. doi: 10.1002/nbm.1788. Epub 2011 Nov 28.
3
Genetically encoded neural activity indicators.基因编码的神经活动指示剂。
Curr Opin Neurobiol. 2012 Feb;22(1):18-23. doi: 10.1016/j.conb.2011.10.024. Epub 2011 Nov 19.
4
Manganese enhanced MRI (MEMRI): neurophysiological applications.锰增强磁共振成像（MEMRI）：神经生理学应用。
Rev Neurosci. 2011;22(6):675-94. doi: 10.1515/RNS.2011.048. Epub 2011 Nov 18.
5
β-Gal gene expression MRI reporter in melanoma tumor cells. Design, synthesis, and in vitro and in vivo testing of a Gd(III) containing probe forming a high relaxivity, melanin-like structure upon β-Gal enzymatic activation.β-半乳糖苷酶基因表达 MRI 报告基因在黑色素瘤肿瘤细胞中的应用。设计、合成及含有 Gd(III)的探针的体外和体内检测，该探针在 β-半乳糖苷酶酶促激活后形成高弛豫性、类似黑色素的结构。
Bioconjug Chem. 2011 Dec 21;22(12):2625-35. doi: 10.1021/bc200486j. Epub 2011 Nov 15.
6
Noninvasive MRI of β-cell function using a Zn2+-responsive contrast agent.利用锌离子响应对比剂进行β细胞功能的无创性 MRI 研究
Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18400-5. doi: 10.1073/pnas.1109649108. Epub 2011 Oct 24.
7
In vivo magnetic resonance imaging of ferritin-based reporter visualizes native neuroblast migration.基于铁蛋白的报告基因的体内磁共振成像可直观呈现天然神经母细胞瘤的迁移。
Neuroimage. 2012 Jan 16;59(2):1004-12. doi: 10.1016/j.neuroimage.2011.08.068. Epub 2011 Sep 13.
8
Manganese-enhanced magnetic resonance imaging.锰增强磁共振成像
Methods Mol Biol. 2011;771:531-68. doi: 10.1007/978-1-61779-219-9_28.
9
Electrical spiking in Escherichia coli probed with a fluorescent voltage-indicating protein.利用荧光电压指示蛋白探测大肠杆菌中的电尖峰。
Science. 2011 Jul 15;333(6040):345-8. doi: 10.1126/science.1204763.
10
Structure-related variable responses of calcium sensitive MRI probes.钙敏 MRI 探针的结构相关可变响应。
Org Biomol Chem. 2011 Aug 21;9(16):5816-24. doi: 10.1039/c1ob05463e. Epub 2011 Jul 5.
Zotero 插件