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本文引用的文献

1
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.Tet 蛋白可以将 5-甲基胞嘧啶转化为 5-醛基胞嘧啶和 5-羧基胞嘧啶。
Science. 2011 Sep 2;333(6047):1300-3. doi: 10.1126/science.1210597. Epub 2011 Jul 21.
2
Characterization of DNA with an 8-oxoguanine modification.8-氧鸟嘌呤修饰的 DNA 特征。
Nucleic Acids Res. 2011 Aug;39(15):6789-801. doi: 10.1093/nar/gkr275. Epub 2011 May 13.
3
Malondialdehyde-deoxyguanosine adduct formation in workers of pathology wards: the role of air formaldehyde exposure.病理学病房工作人员中二醛-脱氧鸟苷加合物的形成：空气甲醛暴露的作用。
Chem Res Toxicol. 2010 Aug 16;23(8):1342-8. doi: 10.1021/tx100083x.
4
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.MLL 蛋白伴侣 TET1 将哺乳动物 DNA 中的 5-甲基胞嘧啶转化为 5-羟甲基胞嘧啶。
Science. 2009 May 15;324(5929):930-5. doi: 10.1126/science.1170116. Epub 2009 Apr 16.
5
Use of DNA adducts to identify human health risk from exposure to hazardous environmental pollutants: the increasing role of mass spectrometry in assessing biologically effective doses of genotoxic carcinogens.利用DNA加合物识别接触有害环境污染物对人类健康的风险：质谱在评估遗传毒性致癌物生物有效剂量中的作用日益凸显。
Mutat Res. 2008 Jul-Aug;659(1-2):68-76. doi: 10.1016/j.mrrev.2008.03.006. Epub 2008 Apr 8.
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Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation.在炎症小鼠模型中，脂质过氧化作用在DNA加合物形成的化学过程中占主导地位。
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A deoxynucleotide derivatization methodology for improving LC-ESI-MS detection.一种用于改进液相色谱-电喷雾电离质谱检测的脱氧核苷酸衍生化方法。
Anal Chem. 2005 Apr 15;77(8):2373-80. doi: 10.1021/ac0483724.
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Bromination of thymine and photochemistry of 5-bromo-6-hydroxyhydrothymine analogues.胸腺嘧啶的溴化反应及5-溴-6-羟基氢胸腺嘧啶类似物的光化学性质
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Cellular background level of 8-oxo-7,8-dihydro-2'-deoxyguanosine: an isotope based method to evaluate artefactual oxidation of DNA during its extraction and subsequent work-up.8-氧代-7,8-二氢-2'-脱氧鸟苷的细胞背景水平：一种基于同位素的方法，用于评估DNA提取及后续处理过程中的人为氧化。
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HPLC isolation and mass spectrometric characterization of two isomers of thymine glycols in oligodeoxynucleotides.寡脱氧核苷酸中胸腺嘧啶二醇两种异构体的高效液相色谱分离及质谱表征
Chem Res Toxicol. 2002 May;15(5):671-6. doi: 10.1021/tx0155855.

基于苯甲酰组氨酸标记-MALDI-TOF/TOF-MS 的非靶向核苷酸分析：在 DNA 中发现可能的 6-氧胸腺嘧啶。

Nontargeted nucleotide analysis based on benzoylhistamine labeling-MALDI-TOF/TOF-MS: discovery of putative 6-oxo-thymine in DNA.

机构信息

Pharmaceutical Science and Barnett Institute, Northeastern University, Boston, Massachusetts 02115, United States.

出版信息

Anal Chem. 2012 Apr 17;84(8):3811-9. doi: 10.1021/ac300532z. Epub 2012 Apr 2.

DOI:10.1021/ac300532z
PMID:22409256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3341171/
Abstract

A method for nontargeted analysis of modified nucleotides in DNA (and RNA) is reported based on labeling with benzoylhistamine (BH) followed by MALDI-MS. The method provides deoxynucleotide-specific detection, accurate measurement of molecular ions, high sensitivity, semiquantitation, and, to the extent studied to date, normalization of response within a factor of <3.

摘要

本文报道了一种基于苯甲酰组氨酸（BH）标记，随后进行 MALDI-MS 的方法，用于对 DNA（和 RNA）中的修饰核苷酸进行非靶向分析。该方法提供了脱氧核苷酸特异性检测、分子离子的精确测量、高灵敏度、半定量以及迄今为止研究范围内的响应归一化（<3 倍因子）。