Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium.
Respir Res. 2012 Mar 16;13(1):21. doi: 10.1186/1465-9921-13-21.
There is a relative lack of information about the death rate and morbidity of non-cystic fibrosis bronchiectasis and most studies are limited due to referral bias. We wanted to assess death rate and morbidity in those patients at our hospital.
Adult patients seen at our department between June 2006 and November 2009 were recruited if the key string "bronchiect-" was mentioned in electronic clinical records and if chest CT imaging was available. Clinical records of all patients with confirmed radiologic diagnosis of bronchiectasis were reviewed and clinical characteristics were analyzed.
539 patients with a radiographic diagnosis of non-cystic fibrosis bronchiectasis were identified in a retrospective cross-sectional analysis giving a prevalence of 2.6% in our hospital population. A wide range of etiologies was found with idiopathic bronchiectasis in 26%. In the 41 months interval, 57 patients (10.6%) died. We found a median exacerbation rate of 1.94 per year. Bacterial colonization status was associated with more deaths, exacerbation rate, symptoms and reduced pulmonary function. Pulmonary hypertension was found in 48% of our patients.
We evaluated a large non-cystic fibrosis bronchiectasis population, and provided new epidemiological data on associations between clinical characteristics and deaths and morbidity in these patients.
非囊性纤维化性支气管扩张症的死亡率和发病率相关信息相对较少，且大多数研究因转诊偏倚而受限。我们希望评估我院此类患者的死亡率和发病率。
如果电子病历中提到关键字符串“bronchiect-”，并且有胸部 CT 成像，则招募 2006 年 6 月至 2009 年 11 月在我院就诊的成年患者。对所有经影像学诊断为支气管扩张症的患者的临床记录进行了回顾，并分析了临床特征。
在回顾性横断面分析中，539 例患者被诊断为非囊性纤维化性支气管扩张症，在我院人群中的患病率为 2.6%。病因广泛，特发性支气管扩张症占 26%。在 41 个月的间隔内，有 57 例（10.6%）患者死亡。我们发现每年的平均恶化率为 1.94 次。细菌定植状态与更多的死亡、恶化率、症状和降低的肺功能有关。我们的患者中有 48%患有肺动脉高压。
我们评估了一个大型非囊性纤维化性支气管扩张症患者人群，并提供了这些患者的临床特征与死亡和发病率之间关联的新的流行病学数据。
