Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, Republic of Korea.
Eur Neurol. 2012;67(4):226-31. doi: 10.1159/000335248. Epub 2012 Mar 15.
As the mesencephalic locomotor center, the pedunculopontine nucleus (PPN) is known to be involved in control of locomotor function. We investigated neural connectivity of the PPN in relation to walking ability in chronic patients with spontaneous intracerebral hemorrhage.
Forty-three consecutive chronic patients with subcortical hemorrhage and 20 healthy control subjects were recruited. A seed region of interest was manually drawn on the PPN and connectivity of the PPN was measured.
In the affected hemisphere, connectivity with the ipsilesional cerebellar locomotor center and connectivity with the contralesional pontine locomotor center were decreased in patients who could not walk, compared with patients who could walk and normal controls (p < 0.05).
Connectivity between the PPN and ipsi-lesional cerebellum locomotor center and contralesional pontine locomotor center in the affected hemisphere appears to be related to walking ability.
被认为是中脑运动中枢的脑桥被盖核（PPN）参与运动功能的控制。我们研究了与自发性脑出血慢性期患者步行能力相关的 PPN 的神经连接。
共纳入 43 例皮质下出血的连续慢性期患者和 20 名健康对照者。手动在 PPN 上绘制感兴趣区种子，测量 PPN 的连接。
在患侧半球，与不能行走的患者相比，能够行走的患者和正常对照组患者的同侧小脑运动中枢与对侧桥脑运动中枢的连接减少（p < 0.05）。
患侧半球 PPN 与同侧小脑运动中枢和对侧桥脑运动中枢之间的连接似乎与步行能力有关。
