Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
Vet Microbiol. 2012 Aug 17;158(3-4):410-4. doi: 10.1016/j.vetmic.2012.02.037. Epub 2012 Mar 2.
Equine group A rotavirus (RVA) strain H-1 (RVA/Horse-tc/GBR/H-1/1975/G5P9[7]) was found to have VP4, VP6-7, NSP1 and NSP4 genes of porcine origin. In order to obtain conclusive information on the exact origin and evolution of this unusual equine strain, the remaining six genes (VP1-3, NSP2-3 and NSP5 genes) of strain H-1 were analyzed in the present study. By whole genomic analysis, strain H-1 exhibited a porcine RVA-like genotype constellation (G5-P[7]-I5-R1-C1-M1-A8-N1-T1-E1-H1), different from those of typical equine RVA strains. The VP2-3 and NSP2-3 genes of strain H-1 were found to originate from porcine RVAs. On the other hand, it was difficult to pinpoint the exact origin of the VP1 and NSP5 genes of strain H-1, though phylogenetically, these genes appeared to be possibly derived from porcine or Wa-like human strains. Taken together, at least nine (VP2-4, VP6-7 and NSP1-4 genes) of the 11 gene segments of strain H-1 were found to be of porcine origin, revealing a porcine RVA-like genetic backbone. Therefore, strain H-1 is likely a porcine RVA strain that was transmitted to horses.
马群 A 轮状病毒（RVA）株 H-1（RVA/Horse-tc/GBR/H-1/1975/G5P9[7]）被发现具有猪源的 VP4、VP6-7、NSP1 和 NSP4 基因。为了获得关于这种不寻常的马源 RVA 株的确切起源和进化的确切信息，本研究对 H-1 株的其余六个基因（VP1-3、NSP2-3 和 NSP5 基因）进行了分析。通过全基因组分析，H-1 株表现出类似于猪源 RVA 的基因型构成（G5-P[7]-I5-R1-C1-M1-A8-N1-T1-E1-H1），与典型的马源 RVA 株不同。H-1 株的 VP2-3 和 NSP2-3 基因源自猪源 RVAs。另一方面，H-1 株的 VP1 和 NSP5 基因的起源很难确定，尽管从系统进化的角度来看，这些基因可能源自猪源或 Wa 样人源株。总的来说，H-1 株的 11 个基因片段中有至少 9 个（VP2-4、VP6-7 和 NSP1-4 基因）源自猪源，显示出类似于猪源 RVA 的遗传骨架。因此，H-1 株可能是一种传播给马的猪源 RVA 株。
