属于不同多位点序列类型的金黄色葡萄球菌分离株呈现出特定的毒力基因谱。
Staphylococcus aureus isolates belonging to different multilocus sequence types present specific virulence gene profiles.
作者信息
Schuenck Ricardo Pinto, Cavalcante Fernanda Sampaio, Emery Eduardo, Giambiagi-de Marval Marcia, dos Santos Katia Regina Netto
机构信息
Departamento de Patologia, Universidade Federal do Espirito Santo, Vitória, Espirito Santo, Brazil.
出版信息
FEMS Immunol Med Microbiol. 2012 Aug;65(3):501-4. doi: 10.1111/j.1574-695X.2012.00958.x. Epub 2012 Apr 16.
To characterize 73 Staphylococcus aureus isolates from infections in an orthopedic hospital in Rio de Janeiro, we investigated the SCCmec types, the clonality by pulsed field gel electrophoresis and multilocus sequence typing, and the presence of virulence genes. Twenty-eight (38.3%) methicillin-resistant (16 SCCmec type IV and 12 type III) isolates were detected. Most (83.5%) of the isolates were included in five lineages: sequence type (ST) 239 (SCCmecIII), 1, 5, 30, and 1462 (SCCmecIV and/or methicillin-susceptible isolates). Virulence genes fnbB, bbp, and pvl were related to STs 239, 30, and 30/1462, respectively. Isolates from STs 1, 5, and 30 presented specific virulence profiles, irrespective of methicillin resistance.
为了对来自里约热内卢一家骨科医院感染患者的73株金黄色葡萄球菌分离株进行特征分析，我们调查了葡萄球菌染色体盒式甲氧西林酶（SCCmec）类型、通过脉冲场凝胶电泳和多位点序列分型确定的克隆性以及毒力基因的存在情况。检测到28株（38.3%）耐甲氧西林菌株（16株为SCCmec IV型，12株为III型）。大多数（83.5%）分离株属于五个谱系：序列类型（ST）239（SCCmec III）、1、5、30和1462（SCCmec IV和/或甲氧西林敏感分离株）。毒力基因fnbB、bbp和pvl分别与ST 239、30和30/1462相关。来自ST 1、5和30的分离株呈现出特定的毒力谱，与甲氧西林耐药性无关。
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