Skogen B, Børresen A L, Natvig J B, Berg K, Michaelsen T E
Scand J Immunol. 1979;10(1):39-45. doi: 10.1111/j.1365-3083.1979.tb01332.x.
In this study present evidence that SAA is complexed to high density lipoprotein (HDL) in rabbit serum and is co-isolated with HDL apoproteins. The binding of SAA to HDL seems to be quite strong, judged from affinity chromatography experiments. The studies did not reveal any interaction between SAA and albumin, and there was no evidence that SAA could complex to itself. By isolation of HDL apoproteins, SAA seems to behave like other known apoproteins and may be characterized as an apoprotein that is present in normal serum in very low concentration but increases in concentration under different unphysiological circumstances.
在本研究中，现有证据表明，血清淀粉样蛋白A（SAA）在兔血清中与高密度脂蛋白（HDL）复合，并与HDL载脂蛋白共同分离。从亲和层析实验判断，SAA与HDL的结合似乎相当牢固。这些研究未揭示SAA与白蛋白之间存在任何相互作用，也没有证据表明SAA能自身复合。通过分离HDL载脂蛋白，SAA的行为似乎与其他已知载脂蛋白相似，可被表征为一种在正常血清中浓度极低，但在不同非生理情况下浓度会升高的载脂蛋白。
