College of Pharmacy, Chungbuk National University, Heungduk-gu, Cheongju, Republic of Korea.
Bioorg Med Chem Lett. 2012 Apr 15;22(8):2760-3. doi: 10.1016/j.bmcl.2012.02.088. Epub 2012 Mar 7.
A new phenolic compound, broussonone A (1) were isolated from the stem barks of Broussonetia kanzinoki (Moraceae), together with two diphenylpropanes, broussonin A (2), broussonin B (3), two flavans, 7,4'-dihydroxyflavan (4), 3',7-dihydroxy-4'-methoxyflavan (5), and two flavones, 3,7-dihydroxy-4'-methoxyflavone (6), 3,7,3'-trihydroxy-4'-methoxyflavone (7). Compound 1 showed noncompetitive inhibitory activity on pancreatic lipase with an IC(50) of 28.4 μM. In addition, compounds 1-5 significantly inhibited adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay.
从构树（桑科）茎皮中分离得到了一个新的酚类化合物 Broussonone A（1），此外还分离得到了两个二苯丙烷化合物 Broussonin A（2）、Broussonin B（3），两个黄烷类化合物 7,4'-二羟基黄烷（4）、3',7-二羟基-4'-甲氧基黄烷（5），两个黄酮类化合物 3,7-二羟基-4'-甲氧基黄酮（6）、3,7,3'-三羟基-4'-甲氧基黄酮（7）。化合物 1 对胰脂肪酶表现出非竞争性抑制活性，IC50 为 28.4 μM。此外，化合物 1-5 在用油红 O 染色法测定脂肪积累时，显著抑制 3T3-L1 细胞中脂肪细胞的分化。
