Department of Neuro-Oncology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 431, Houston, TX 77030, USA.
Curr Neurol Neurosci Rep. 2012 Jun;12(3):267-75. doi: 10.1007/s11910-012-0264-9.
Many cancer patients develop treatment-related cognitive dysfunction that affects their quality of life and can result in diminished functional independence. There is an emerging body of transdisciplinary research demonstrating that chemotherapeutic agents can produce neurobiological changes within the brain, which are associated with a constellation of cognitive changes that can result in decreased quality of life and functional independence. The increased incidence of cancer, coupled with longer survival times, has resulted in larger numbers of cancer survivors who are struggling with this neurotoxicity. This review summarizes the neuropsychological findings in patients with breast and brain cancer who receive systemic chemotherapy as well as the recent animal and imaging research elucidating the mechanisms by which these therapies impact brain structure, function, and consequent behavior.
许多癌症患者会出现与治疗相关的认知功能障碍，这会影响他们的生活质量，并导致其功能独立性下降。越来越多的跨学科研究表明，化疗药物会在大脑内引起神经生物学变化，这些变化与一系列认知变化相关，从而导致生活质量和功能独立性下降。癌症发病率的增加，加上生存时间的延长，导致越来越多的癌症幸存者正在与这种神经毒性作斗争。这篇综述总结了接受全身化疗的乳腺癌和脑癌患者的神经心理学发现，以及最近的动物和影像学研究阐明了这些治疗方法影响大脑结构、功能和随后行为的机制。
