Nanomaterials Laboratory, Department of Physics, Insitute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Adv Exp Med Biol. 2012;740:891-916. doi: 10.1007/978-94-007-2888-2_40.
The increasing interest in stem cell research is linked to the promise of developing treatments for many lifethreatening, debilitating diseases, and for cell replacement therapies. However, performing these therapeutic innovations with safety will only be possible when an accurate knowledge about the molecular signals that promote the desired cell fate is reached. Among these signals are transient changes in intracellular Ca(2+) concentration Ca(2+). Acting as an intracellular messenger, Ca(2+) has a key role in cell signaling pathways in various differentiation stages of stem cells. The aim of this chapter is to present a broad overview of various moments in which Ca(2+)-mediated signaling is essential for the maintenance of stem cells and for promoting their development and differentiation, also focusing on their therapeutic potential.
人们对干细胞研究的兴趣日益浓厚，这与开发治疗许多危及生命、使人虚弱的疾病和细胞替代疗法的前景有关。然而，只有当我们准确地了解促进所需细胞命运的分子信号时，这些治疗创新才有可能安全进行。这些信号包括细胞内钙离子浓度 Ca(2+) 的短暂变化。Ca(2+) 作为细胞内信使，在干细胞的各种分化阶段的细胞信号通路中起着关键作用。本章的目的是广泛概述 Ca(2+)-介导的信号在维持干细胞和促进其发育和分化方面的重要作用，同时也关注它们的治疗潜力。
