Department of Biomedical Engineering, Washington University in St. Louis, 390E Whitaker Hall, One Brookings Drive, St. Louis, MO 63130, USA.
Adv Exp Med Biol. 2012;740:1145-74. doi: 10.1007/978-94-007-2888-2_52.
Heart failure (HF) is an increasing public health problem accelerated by a rapidly aging global population. Despite considerable progress in managing the disease, the development of new therapies for effective treatment of HF remains a challenge. To identify targets for early diagnosis and therapeutic intervention, it is essential to understand the molecular and cellular basis of calcium handling and the signaling pathways governing the functional remodeling associated with HF in humans. Calcium (Ca(2+)) cycling is an essential mediator of cardiac contractile function, and remodeling of calcium handling is thought to be one of the major factors contributing to the mechanical and electrical dysfunction observed in HF. Active research in this field aims to bridge the gap between basic research and effective clinical treatments of HF. This chapter reviews the most relevant studies of calcium remodeling in failing human hearts and discusses their connections to current and emerging clinical therapies for HF patients.
心力衰竭（HF）是一个日益严重的公共卫生问题，加速了全球人口的快速老龄化。尽管在管理该病方面取得了相当大的进展，但开发新的治疗方法以有效治疗 HF 仍然是一个挑战。为了确定早期诊断和治疗干预的靶点，了解钙处理的分子和细胞基础以及调节与 HF 相关的功能重构的信号通路对于人类至关重要。钙（Ca（2+））循环是心脏收缩功能的重要介质，钙处理的重构被认为是导致 HF 中观察到的机械和电功能障碍的主要因素之一。该领域的积极研究旨在弥合基础研究与 HF 有效临床治疗之间的差距。本章回顾了心力衰竭患者中钙重构的最相关研究，并讨论了它们与 HF 患者当前和新兴临床治疗方法的联系。
