Oliveira-Neto Antonio, Parpinelli Mary A, Cecatti Jose G, Souza Joao P, Sousa Maria H
Intensive Care Unit, Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
ScientificWorldJournal. 2012;2012:172145. doi: 10.1100/2012/172145. Epub 2012 Feb 14.
To evaluate the performance of Sequential Organ Failure Assessment (SOFA) score in cases of severe maternal morbidity (SMM).
Retrospective study of diagnostic validation. Setting. An obstetric intensive care unit (ICU) in Brazil. Population. 673 women with SMM.
mortality and SOFA score. Methods. Organ failure was evaluated according to maximum score for each one of its six components. The total maximum SOFA score was calculated using the poorest result of each component, reflecting the maximum degree of alteration in systemic organ function.
highest total maximum SOFA score was associated with mortality, 12.06 ± 5.47 for women who died and 1.87 ± 2.56 for survivors. There was also a significant correlation between the number of failing organs and maternal mortality, ranging from 0.2% (no failure) to 85.7% (≥3 organs). Analysis of the area under the receiver operating characteristic (ROC) curve (AUC) confirmed the excellent performance of total maximum SOFA score for cases of SMM (AUC = 0.958).
Total maximum SOFA score proved to be an effective tool for evaluating severity and estimating prognosis in cases of SMM. Maximum SOFA score may be used to conceptually define and stratify the degree of severity in cases of SMM.
评估序贯器官衰竭评估（SOFA）评分在严重孕产妇发病（SMM）病例中的表现。
诊断验证的回顾性研究。地点：巴西的一家产科重症监护病房（ICU）。研究对象：673例患有SMM的女性。
死亡率和SOFA评分。方法：根据其六个组成部分中每个部分的最高分评估器官衰竭情况。总最大SOFA评分通过每个组成部分的最差结果计算得出，反映全身器官功能改变的最大程度。
总最大SOFA评分最高与死亡率相关，死亡女性为12.06±5.47，存活者为1.87±2.56。衰竭器官数量与孕产妇死亡率之间也存在显著相关性，范围从0.2%（无衰竭）到85.7%（≥3个器官）。对受试者工作特征（ROC）曲线下面积（AUC）的分析证实了总最大SOFA评分在SMM病例中的出色表现（AUC = 0.958）。
总最大SOFA评分被证明是评估SMM病例严重程度和估计预后的有效工具。最大SOFA评分可用于从概念上定义和分层SMM病例的严重程度。
