Department of Family Medicine, School of Medicine, Jeju National University, Jeju 690-756, Republic of Korea.
Evid Based Complement Alternat Med. 2012;2012:732915. doi: 10.1155/2012/732915. Epub 2012 Feb 20.
Objectives. Human placental extract (HPE) has begun to be used in Korea in various ways to improve health, even though evidence-based data is insufficient. This study investigated the effects of HPE on health status in elderly Koreans. Design. Randomized, single-blind, and case-control study design. Setting and Participants. Thirty-nine community-dwelling healthy Koreans ≥65 years of age. Intervention. The participants were randomly categorized into a placebo group (n = 17) and HPE group (n = 22). The HPE group received abdominal subcutaneous injections of HPE for 8 weeks. The placebo group was injected with normal saline. Measurements. The degree of health status was surveyed by the Korean health status measure for the elderly (KoHSME V1.0) at baseline and the end of the study. Results. In the HPE group, the scores of physical function, sexual life, and general heath perception at the end of the study period were significantly improved from baseline (P = .007, .020, and .005, resp.), while the health status of the placebo group remained unchanged during the study period. There was a significant difference over the study period between the two groups in the mean change of the physical function score (P = .036). Conclusion. A HPE injection regimen can improve the health status in elderly Koreans.
尽管缺乏基于证据的数据，但人类胎盘提取物（HPE）已开始在韩国以各种方式被用于改善健康，本研究旨在探究 HPE 对韩国老年人健康状况的影响。
随机、单盲、病例对照研究设计。
39 名居住在社区的健康韩国老年人（年龄≥65 岁）。
参与者被随机分为安慰剂组（n = 17）和 HPE 组（n = 22）。HPE 组接受 HPE 腹部皮下注射 8 周，安慰剂组注射生理盐水。
健康状况通过韩国老年人健康状况量表（KoHSME V1.0）在基线和研究结束时进行评估。
在 HPE 组中，研究结束时的身体功能、性生活和一般健康感知评分与基线相比显著改善（P =.007，P =.020 和 P =.005），而安慰剂组在研究期间健康状况保持不变。在研究期间，两组之间身体功能评分的平均变化有显著差异（P =.036）。
HPE 注射方案可以改善韩国老年人的健康状况。
