Long Manhai, Bossi Rossana, Bonefeld-Jørgensen Eva C
Aarhus University, School of Public Health, Centre of Arctic Environmental Medicine, Aarhus, Denmark.
Int J Circumpolar Health. 2012 Mar 19;71:17998. doi: 10.3402/ijch.v71i0.17998.
Perfluoroalkyl acids (PFAAs) have been detected in human blood, breast milk and umbilical cord blood across the globe. PFAAs do accumulate in the marine food chain in Arctic regions. In Greenland, increasing PFAA concentrations were observed during 1982-2006 in ringed seals and polar bears. However, until now, no data have been reported for PFAAs in Greenlandic Inuit. This study assesses the level and temporal trend of serum PFAAs in Greenlandic Inuit.
Cross-section and temporal time trend survey.
Serum PFAA levels were determined in 284 Inuit from different Greenlandic districts using liquid chromatography-tandem mass spectrometry with electrospray ionization. The temporal time trend of serum PFAAs in Nuuk Inuit during 1998-2005 and the correlation between serum PFAAs and legacy persistent organic pollutants (POPs) were explored.
Serum PFAA levels were higher in Nuuk Inuit than in non-Nuuk Inuit. Within the same district, higher PFAA levels were observed for males. An age-dependent, increasing trend of serum PFAA levels in the period from 1998-2005 was observed for Nuuk Inuit. For the pooled gender data, no significant association between PFAAs and legacy POPs was observed for Nuuk Inuit while for non-Nuuk Inuit this correlation was significant. No correlation between PFAAs and legacy POPs was found for male Inuit, whereas significant correlation was observed both for pooled female Inuit and for non-Nuuk Inuit females.
We suggest that sources other than seafood intake might contribute to the observed higher PFAA levels in Nuuk Inuit compared to the pooled non-Nuuk Inuit.
在全球范围内，全氟烷基酸（PFAA）已在人体血液、母乳和脐带血中被检测到。PFAA在北极地区的海洋食物链中会累积。在格陵兰岛，1982年至2006年期间，环斑海豹和北极熊体内的PFAA浓度不断上升。然而，迄今为止，尚未有关于格陵兰因纽特人PFAA的数据报告。本研究评估了格陵兰因纽特人血清PFAA的水平和时间趋势。
横断面和时间趋势调查。
使用电喷雾电离液相色谱 - 串联质谱法测定了来自格陵兰不同地区的284名因纽特人的血清PFAA水平。探讨了1998年至2005年期间努克因纽特人血清PFAA的时间趋势以及血清PFAA与遗留持久性有机污染物（POPs）之间的相关性。
努克因纽特人的血清PFAA水平高于非努克因纽特人。在同一地区，男性的PFAA水平更高。1998年至2005年期间，努克因纽特人血清PFAA水平呈现出随年龄增长而上升的趋势。对于汇总的性别数据，努克因纽特人PFAA与遗留POPs之间未观察到显著关联，而非努克因纽特人则存在显著相关性。男性因纽特人PFAA与遗留POPs之间未发现相关性，而汇总的女性因纽特人和非努克因纽特女性均观察到显著相关性。
我们认为，与汇总的非努克因纽特人相比，努克因纽特人血清PFAA水平较高，其原因可能并非仅来自海鲜摄入。
