晚期糖基化终末产物受体（RAGE）及其在心力衰竭病理生理学中的意义。
Receptor for advanced glycation end products (RAGE) and implications for the pathophysiology of heart failure.
作者信息
Ramasamy Ravichandran, Schmidt Ann Marie
机构信息
Diabetes Research Program, Division of Endocrinology, Department of Medicine, NYU School of Medicine, 550 First Avenue, Smilow 901, New York, NY, 10016, USA.
出版信息
Curr Heart Fail Rep. 2012 Jun;9(2):107-16. doi: 10.1007/s11897-012-0089-5.
Abstract
The receptor for advanced glycation end products (RAGE) is expressed in the heart in cardiomyocytes, vascular cells, fibroblasts, and in infiltrating inflammatory cells. Experiments in murine, rat, and swine models of injury suggest that RAGE and the ligands of RAGE are upregulated in key injuries to the heart, including ischemia/reperfusion injury, diabetes, and inflammation. Pharmacological antagonism of RAGE or genetic deletion of the receptor in mice is strikingly protective in models of these stresses. Data emerging from human studies suggest that measurement of levels of RAGE ligands or soluble RAGEs in plasma or serum may correlate with the degree of heart failure. Taken together, the ligand-RAGE axis is implicated in heart failure and we predict that therapeutic antagonism of RAGE might be a unique target for therapeutic intervention in this disorder.
摘要
晚期糖基化终末产物受体（RAGE）在心脏的心肌细胞、血管细胞、成纤维细胞以及浸润的炎性细胞中表达。在小鼠、大鼠和猪的损伤模型中进行的实验表明，在心脏的关键损伤（包括缺血/再灌注损伤、糖尿病和炎症）中，RAGE及其配体的表达上调。在这些应激模型中，对小鼠进行RAGE的药理学拮抗或受体的基因敲除具有显著的保护作用。来自人体研究的数据表明，测量血浆或血清中RAGE配体或可溶性RAGE的水平可能与心力衰竭的程度相关。综上所述，配体-RAGE轴与心力衰竭有关，我们预测RAGE 的治疗性拮抗可能是针对这种疾病进行治疗干预的独特靶点。
相似文献
1
Receptor for advanced glycation end products (RAGE) and implications for the pathophysiology of heart failure.晚期糖基化终末产物受体（RAGE）及其在心力衰竭病理生理学中的意义。
Curr Heart Fail Rep. 2012 Jun;9(2):107-16. doi: 10.1007/s11897-012-0089-5.
2
Soluble RAGE: therapy and biomarker in unraveling the RAGE axis in chronic disease and aging.可溶性 RAGE：在慢性疾病和衰老的 RAGE 轴中解开谜团的治疗和生物标志物。
Biochem Pharmacol. 2010 May 15;79(10):1379-86. doi: 10.1016/j.bcp.2010.01.013. Epub 2010 Jan 22.
3
The receptor for advanced glycation endproducts (RAGE) and cardiovascular disease.晚期糖基化终末产物受体（RAGE）与心血管疾病
Expert Rev Mol Med. 2009 Mar 12;11:e9. doi: 10.1017/S146239940900101X.
4
RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model.在小鼠模型中，晚期糖基化终末产物受体（RAGE）通过影响JNK和STAT信号传导来调节因左前降支梗死所致的心肌损伤。
Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1823-32. doi: 10.1152/ajpheart.01210.2007. Epub 2008 Feb 1.
5
RAGE modulates hypoxia/reoxygenation injury in adult murine cardiomyocytes via JNK and GSK-3beta signaling pathways.RAGE 通过 JNK 和 GSK-3β信号通路调节成年鼠心肌细胞缺氧/复氧损伤。
PLoS One. 2010 Apr 9;5(4):e10092. doi: 10.1371/journal.pone.0010092.
6
Receptor for advanced glycation end products mediates inflammation and enhanced expression of tissue factor in vasculature of diabetic apolipoprotein E-null mice.晚期糖基化终末产物受体介导糖尿病载脂蛋白E基因敲除小鼠血管炎症及组织因子表达增强。
Arterioscler Thromb Vasc Biol. 2001 Jun;21(6):905-10. doi: 10.1161/01.atv.21.6.905.
7
Receptor for advanced glycation end products: fundamental roles in the inflammatory response: winding the way to the pathogenesis of endothelial dysfunction and atherosclerosis.晚期糖基化终末产物受体：在炎症反应中的重要作用——通向内皮功能障碍和动脉粥样硬化发病机制之路
Ann N Y Acad Sci. 2008 Apr;1126:7-13. doi: 10.1196/annals.1433.056.
8
Receptor for advanced glycation end products (RAGE) on iNKT cells mediates lung ischemia-reperfusion injury.iNKT 细胞上的晚期糖基化终产物受体（RAGE）介导肺缺血再灌注损伤。
Am J Transplant. 2013 Sep;13(9):2255-67. doi: 10.1111/ajt.12368. Epub 2013 Jul 19.
9
Receptor for advanced glycation end products and its ligands: a journey from the complications of diabetes to its pathogenesis.晚期糖基化终末产物受体及其配体：从糖尿病并发症到发病机制的探索之旅。
Ann N Y Acad Sci. 2005 Jun;1043:553-61. doi: 10.1196/annals.1338.063.
10
AGEs-RAGE axis mediates myocardial fibrosis via activation of cardiac fibroblasts induced by autophagy in heart failure.AGEs-RAGE 轴通过自噬诱导的心肌成纤维细胞激活介导心力衰竭中的心肌纤维化。
Exp Physiol. 2022 Aug;107(8):879-891. doi: 10.1113/EP090042. Epub 2022 Jun 2.
引用本文的文献
1
The Role of Advanced Glycation End-Products in the Pathophysiology and Pharmacotherapy of Cardiovascular Disease.晚期糖基化终末产物在心血管疾病病理生理学及药物治疗中的作用
Int J Mol Sci. 2025 Jul 29;26(15):7311. doi: 10.3390/ijms26157311.
2
Amyloid-β and heart failure in Alzheimer's disease: the new vistas.阿尔茨海默病中的β-淀粉样蛋白与心力衰竭：新视野
Front Med (Lausanne). 2025 Feb 4;12:1494101. doi: 10.3389/fmed.2025.1494101. eCollection 2025.
3
Metabolite signaling in the heart.心脏中的代谢物信号传递。
Nat Cardiovasc Res. 2023 Jun;2(6):504-516. doi: 10.1038/s44161-023-00270-6. Epub 2023 May 25.
4
Glycation in the cardiomyocyte.心肌细胞中的糖基化作用。
Vitam Horm. 2024;125:47-88. doi: 10.1016/bs.vh.2024.04.005. Epub 2024 May 24.
5
Effects of protein glycation and protective mechanisms against glycative stress.蛋白质糖化的影响和对抗糖化应激的保护机制。
Curr Opin Pharmacol. 2024 Jun;76:102464. doi: 10.1016/j.coph.2024.102464. Epub 2024 May 25.
6
Biomedical applications of artificial exosomes for intranasal drug delivery.用于鼻内给药的人工外泌体的生物医学应用。
Front Bioeng Biotechnol. 2023 Sep 7;11:1271489. doi: 10.3389/fbioe.2023.1271489. eCollection 2023.
7
Molecular and cellular pathophysiology of circulating cardiomyocyte-specific cell free DNA (cfDNA): Biomarkers of heart failure and potential therapeutic targets.循环心肌细胞特异性游离DNA（cfDNA）的分子与细胞病理生理学：心力衰竭的生物标志物及潜在治疗靶点
Genes Dis. 2022 Aug 31;10(3):948-959. doi: 10.1016/j.gendis.2022.08.008. eCollection 2023 May.
8
Emergent Inflammatory Markers and Echocardiographic Indices in Patients with Bronchial Asthma.支气管哮喘患者的紧急炎症标志物和超声心动图指数。
Biomolecules. 2023 Jun 7;13(6):955. doi: 10.3390/biom13060955.
9
Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging.通过单正电子发射计算机断层扫描/计算机断层扫描成像从动态心脏成像数据中反卷积血浆药代动力学。
J Pharmacol Exp Ther. 2023 Jul;386(1):102-110. doi: 10.1124/jpet.122.001545. Epub 2023 May 23.
10
Relationship between Oxidative Stress and Left Ventricle Markers in Patients with Chronic Heart Failure.氧化应激与慢性心力衰竭患者左心室标志物的关系。
Cells. 2023 Mar 4;12(5):803. doi: 10.3390/cells12050803.
本文引用的文献
1
Opposing roles of RAGE and Myd88 signaling in extensive liver resection.RAGE 和 Myd88 信号在广泛肝切除中的相反作用。
FASEB J. 2012 Feb;26(2):882-93. doi: 10.1096/fj.11-192997. Epub 2011 Nov 10.
2
Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients.在癌症患者中通过直接组合选择进行血管配体-受体作图。
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18637-42. doi: 10.1073/pnas.1114503108. Epub 2011 Nov 2.
3
RAGE: a single receptor fits multiple ligands.RAGE：一个受体对应多种配体。
Trends Biochem Sci. 2011 Dec;36(12):625-32. doi: 10.1016/j.tibs.2011.08.008. Epub 2011 Oct 19.
4
S100B-RAGE dependent VEGF secretion by cardiac myocytes induces myofibroblast proliferation.心肌细胞 S100B-RAGE 依赖性 VEGF 分泌诱导成纤维细胞增殖。
J Mol Cell Cardiol. 2012 Feb;52(2):464-73. doi: 10.1016/j.yjmcc.2011.08.015. Epub 2011 Aug 23.
5
sRAGE in diabetic and non-diabetic critically ill patients: effects of intensive insulin therapy.糖尿病和非糖尿病危重症患者中 sRAGE：强化胰岛素治疗的影响。
Crit Care. 2011 Aug 26;15(4):R203. doi: 10.1186/cc10420.
6
Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 diabetes: an analysis from the CARDS trial.总可溶性及内源性晚期糖基化终产物受体作为 2 型糖尿病患者冠心病风险预测生物标志物的研究：来自 CARDS 试验的分析。
Diabetes. 2011 Sep;60(9):2379-85. doi: 10.2337/db11-0291. Epub 2011 Jul 19.
7
Advanced glycation end product recognition by the receptor for AGEs.晚期糖基化终末产物通过 AGEs 受体被识别。
Structure. 2011 May 11;19(5):722-32. doi: 10.1016/j.str.2011.02.013.
8
Calcium channel blocker inhibition of AGE and RAGE axis limits renal injury in nondiabetic patients with stage I or II chronic kidney disease.钙通道阻滞剂抑制 AGE 和 RAGE 轴可限制非糖尿病 I 期或 II 期慢性肾脏病患者的肾脏损伤。
Clin Cardiol. 2011 Jun;34(6):372-7. doi: 10.1002/clc.20885. Epub 2011 Mar 22.
9
Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells.晚期糖基化终产物受体与磷脂酰丝氨酸结合，并协助清除凋亡细胞。
EMBO Rep. 2011 Apr;12(4):358-64. doi: 10.1038/embor.2011.28. Epub 2011 Mar 11.
10
HMGB1 as a predictor of infarct transmurality and functional recovery in patients with myocardial infarction.高迁移率族蛋白 B1 作为心肌梗死患者梗死透壁程度和功能恢复的预测因子。
J Intern Med. 2011 Sep;270(3):245-53. doi: 10.1111/j.1365-2796.2011.02369.x. Epub 2011 Mar 28.
Zotero 插件