Keet I P, Lee F K, van Griensven G J, Lange J M, Nahmias A, Coutinho R A
Department of Infectious Diseases, Municipal Health Service, Amsterdam, The Netherlands.
Genitourin Med. 1990 Oct;66(5):330-3. doi: 10.1136/sti.66.5.330.
We studied the role of genital ulcerative infections for acquisition of human immunodeficiency virus type 1 (HIV-1) infection in a cohort of 989 homosexual men in Amsterdam between October 1984 and December 1988. Among 53 HIV-1 seroconverters serological and anamnestic data were gathered regarding herpes simplex virus type 2 (HSV-2) and syphilis in the 6 months before seroconversion. For statistical analysis a control who remained seronegative during the same interval was selected at random for each HIV-1 seroconverter. A significant difference between the prevalence of HSV-2 antibodies among HIV-1 seroconverters and controls was found (72% vs 38%). HSV-2 seroconversions among men initially seronegative for HSV-2 were found among three of 18 HIV-1 seroconverters and among three of 36 controls. (O.R. = 2.2, 95% C.I. 0.4-12.1). Self-reported cases of anogenital herpes were found more frequently among HIV-1 seroconverters (8) than among controls (4). One case of syphilis was diagnosed among HIV-1 seroconverters, and one among controls. Summing up these cases we assessed the total number of genital ulcerative infections: 12 among HIV-1 seroconverters and eight among controls (23 vs 15%, O.R. 1.7, C.I. 0.6-4.62). These data suggest little evidence for genital ulcerative infections being an important independent risk factor for HIV-1 acquisition among homosexual men in Amsterdam during the time period studied.
1984年10月至1988年12月期间，我们在阿姆斯特丹的989名同性恋男性队列中研究了生殖器溃疡性感染在获得1型人类免疫缺陷病毒（HIV-1）感染中的作用。在53名HIV-1血清转化者中，收集了血清转化前6个月内关于2型单纯疱疹病毒（HSV-2）和梅毒的血清学及既往史数据。为进行统计分析，为每名HIV-1血清转化者随机选择一名在同一时期内仍为血清阴性的对照者。发现HIV-1血清转化者和对照者中HSV-2抗体患病率存在显著差异（72%对38%）。在最初HSV-2血清阴性的男性中，18名HIV-1血清转化者中有3名出现了HSV-2血清转化，36名对照者中有3名出现了HSV-2血清转化。（比值比=2.2，95%可信区间0.4-12.1）。自我报告的肛门生殖器疱疹病例在HIV-1血清转化者（8例）中比在对照者（4例）中更常见。HIV-1血清转化者中诊断出1例梅毒，对照者中诊断出1例梅毒。汇总这些病例后，我们评估了生殖器溃疡性感染的总数：HIV-1血清转化者中有12例，对照者中有8例（23%对15%，比值比1.7，可信区间0.6-4.62）。这些数据表明，在所研究的时间段内，几乎没有证据表明生殖器溃疡性感染是阿姆斯特丹同性恋男性中获得HIV-1的重要独立危险因素。
