Stamm W E, Handsfield H H, Rompalo A M, Ashley R L, Roberts P L, Corey L
Department of Medicine, University of Washington School of Medicine, Seattle.
JAMA. 1988 Sep 9;260(10):1429-33.
We analyzed the association of herpes simplex virus (HSV) infection and syphilis, the two most common causes of genital ulceration in homosexual men, with human immunodeficiency virus (HIV) infection in 200 men enrolled between 1983 and 1986 into a study evaluating the microbial causes of acute proctitis. Infection with HIV was independently associated with a history of syphilis, serologic evidence of syphilis, a history of HSV infection, and antibody to HSV-2. Antibody to HIV was not associated with a history of other genital infections or with antibody to Chlamydia trachomatis or HSV-1. Similar associations were observed in 111 asymptomatic homosexuals seen for HIV screening. Men who presented with primary HSV proctitis had a lower prevalence of HIV antibody than those with preexisting HSV-2 antibody (44% vs 68%); this suggests that HSV-2 infection antedated HIV infection. These data suggest that genital ulcerative diseases are an important risk factor for the acquisition of HIV infection in homosexual men; measures directed at control of these diseases may reduce the transmission of HIV in this population.
我们分析了单纯疱疹病毒（HSV）感染和梅毒这两种男同性恋者生殖器溃疡最常见的病因，与1983年至1986年间纳入一项评估急性直肠炎微生物病因研究的200名男性中人类免疫缺陷病毒（HIV）感染之间的关联。HIV感染与梅毒病史、梅毒血清学证据、HSV感染病史以及抗HSV - 2抗体独立相关。抗HIV抗体与其他生殖器感染病史或抗沙眼衣原体或HSV - 1抗体无关。在111名因HIV筛查前来就诊的无症状同性恋者中也观察到了类似的关联。出现原发性HSV直肠炎的男性中HIV抗体的患病率低于已有HSV - 2抗体的男性（44%对68%）；这表明HSV - 2感染早于HIV感染。这些数据表明，生殖器溃疡性疾病是男同性恋者感染HIV的一个重要危险因素；针对控制这些疾病的措施可能会减少该人群中HIV的传播。
