ERSSCa & Biostatistiques, recherche clinique et mesures subjectives en santé (EA 4275), Faculty of Medicine, 9 rue Bias, Nantes, France.
Eur J Cancer Care (Engl). 2012 Sep;21(5):692-700. doi: 10.1111/j.1365-2354.2012.01344.x. Epub 2012 Apr 4.
Research concerning long-term breast cancer survivors (BCS) has primarily analysed their health-related quality of life (HRQoL). However, other dimensions of life considered important by patients might be affected by cancer treatments as well. The aim of this paper is thus to compare the clinical determinants of HRQoL and of overall quality of life as described by measures of subjective well-being (SWB) in long-term BCS. SWB represents a person's own evaluation of their overall situation. A total of 321 French BCS diagnosed 5 to 15 years ago participated in a cross-sectional mailed survey. Outcome measures were the physical and mental health scores of the 36-item Short-Form survey and measures of SWB (happiness, life satisfaction and the positive and negative affect scales). Multivariate regression analyses suggest that HRQoL and SWB measures provide different pictures of the experience of breast cancer. Treatment type has no impact on HRQoL but is correlated with all our SWB measures while time since diagnosis positively affects physical health but not SWB. We conclude that it could be fruitful to analyse SWB, alongside the traditional study of HRQoL, in order to enhance our understanding of the various long-lasting consequences of breast cancer.
本研究旨在比较长期乳腺癌幸存者（BCS）的健康相关生活质量（HRQoL）和主观幸福感（SWB）测量所描述的整体生活质量的临床决定因素。SWB 代表一个人对其整体状况的自我评估。共有 321 名法国 BCS 患者参与了这项横断面邮寄调查，这些患者在 5 至 15 年前被诊断为乳腺癌。结果测量指标包括 36 项简短健康调查的身体和心理健康评分以及 SWB 测量指标（幸福感、生活满意度以及积极和消极情绪量表）。多变量回归分析表明，HRQoL 和 SWB 测量结果提供了乳腺癌体验的不同画面。治疗类型对 HRQoL 没有影响，但与我们所有的 SWB 测量指标相关，而诊断后时间的长短则对身体健康有积极影响，但对 SWB 没有影响。我们的结论是，分析 SWB 与传统的 HRQoL 研究相结合，可能有助于我们更深入地了解乳腺癌的各种长期后果。
