Jeong Hye Sook, Jeong Ahyong, Cheon Doo-Sung
Division of Enteric and Hepatitis Viruses, Center for Infectious Disease, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongwon, Korea.
Korean J Pediatr. 2012 Mar;55(3):77-82. doi: 10.3345/kjp.2012.55.3.77. Epub 2012 Mar 16.
Human astrovirus (HAstV) is a major cause of acute diarrhea among children, resulting in outbreaks of diarrhea and occasionally hospitalization. Improved surveillance and application of sensitive molecular diagnostics have further defined the impact of HAstV infections in children. These studies have shown that HAstV infections are clinically milder (diarrhea, vomiting, fever) than infections with other enteric agents. Among the 8 serotypes of HAstV identified, serotype 1 is the predominant strain worldwide. In addition to serotype 1, the detection rate of HAstV types 2 to 8 has increased by using newly developed assays. HAstV is less common compared with other major gastroenteritis viruses, including norovirus and rotavirus; however, it is a potentially important viral etiological agent with a significant role in acute gastroenteritis. A better understanding of the molecular epidemiology and characteristics of HAstV strains may be valuable to develop specific prevention strategies.
人星状病毒（HAstV）是儿童急性腹泻的主要病因，可导致腹泻暴发，偶尔还会导致住院治疗。加强监测以及应用灵敏的分子诊断方法，进一步明确了HAstV感染对儿童的影响。这些研究表明，HAstV感染在临床上比其他肠道病原体感染的症状要轻（腹泻、呕吐、发热）。在已鉴定出的8种HAstV血清型中，血清型1是全球主要毒株。除血清型1外，通过新开发的检测方法，HAstV 2至8型的检出率有所提高。与其他主要的肠胃炎病毒（包括诺如病毒和轮状病毒）相比，HAstV相对少见；然而，它是一种潜在的重要病毒病原体，在急性肠胃炎中起着重要作用。更好地了解HAstV毒株的分子流行病学和特征，可能有助于制定具体的预防策略。
