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[从血培养中分离出的念珠菌属的体外药敏研究]

[Study on in vitro susceptibility of Candida spp. isolated from blood culture].

作者信息

Grandesso Stefano, Sapino Barbara, Mazzuccato Sandra, Solinas Maria, Bedin Maria, D'Angelo Monica, Gion Massimo

机构信息

Struttura Semplice Dipartimentale di Microbiologia, Ospedale dell'Angelo, Mestre, Venezia, Italy.

出版信息

Infez Med. 2012 Mar;20(1):25-30.

Abstract

In recent years the incidence of bloodstream infections due to Candida species has progressively increased, partly due to the more critical conditions of hospitalized patients. There has been a significant increase in immune-compromised, diabetic and/or elderly patients, also with venous access, with a subsequent increase in Candida species isolated from bloodstream infections. In 2009-2010 in the hospitals of Mestre and Venice we isolated 123 Candida species from bloodstream infections: 59 Candida albicans, 28 Candida parapsilosis, 12 Candida glabrata, 9 Candida tropicalis, and 4 Geotrichum capitatum, while the 11 others belong to 8 different species. We calculated MIC for the following antifungal agents: fluconazole, itraconazole, voriconazole, 5-flucytosine, amphotericin B and caspofungin.

摘要

近年来,念珠菌属引起的血流感染发病率逐渐上升,部分原因是住院患者病情更为危重。免疫功能低下、糖尿病和/或老年患者数量显著增加,且这些患者也有静脉通路,随后从血流感染中分离出的念珠菌属也有所增加。2009 - 2010年,我们在梅斯特雷和威尼斯的医院从血流感染中分离出123株念珠菌属:59株白色念珠菌、28株近平滑念珠菌、12株光滑念珠菌、9株热带念珠菌和4株头状地霉,而其他11株属于8个不同的种。我们计算了以下抗真菌药物的最低抑菌浓度:氟康唑、伊曲康唑、伏立康唑、5-氟胞嘧啶、两性霉素B和卡泊芬净。

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