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UV and near-IR triggered release from polymeric nanoparticles.聚合物纳米粒子的紫外和近红外触发释放。
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Dendritic chain reaction: responsive release of hydrogen peroxide upon generation and enzymatic oxidation of methanol.树突链反应：甲醇生成和酶氧化时过氧化氢的响应性释放。
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Remarkable drug-release enhancement with an elimination-based AB3 self-immolative dendritic amplifier.基于消除作用的AB3自牺牲树枝状放大器实现显著的药物释放增强。
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通过自焚树枝状支架增加材料对双光子近红外光的响应。

Increasing materials' response to two-photon NIR light via self-immolative dendritic scaffolds.

机构信息

Skaggs School Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, USA.

出版信息

Chem Commun (Camb). 2012 Sep 21;48(73):9138-40. doi: 10.1039/c2cc00072e. Epub 2012 Apr 5.

DOI:10.1039/c2cc00072e
PMID:22475792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3421069/
Abstract

Photoactivation using two photons of NIR allows non-invasive biological manipulation. We applied the principle of dendritic amplification to improve the materials' sensitivity to NIR light. Light induced uncaging or release of L-glutamic acid was 2.8 fold higher when incorporating 4-bromo-7-hydroxycoumarin (Bhc) with self-immolative dendrimers compared with Bhc directly conjugated to L-glutamic acid.

摘要

利用近红外光的双光子光激活可实现非侵入式的生物操控。我们将树突状放大原理应用于提高材料对近红外光的敏感性。与直接与 L-谷氨酸偶联的 Bhc 相比，将 4-溴-7-羟基香豆素（Bhc）与自耗散树突状聚合物结合时，光诱导的 L-谷氨酸解笼或释放提高了 2.8 倍。