Tropical Medicine, Infectious Diseases Department, Hospital Universitario Ramón y Cajal, IRYCIS, Carretera de Colmenar Km 9,1, 28034, Madrid, Spain,
Curr Infect Dis Rep. 2012 Jun;14(3):263-74. doi: 10.1007/s11908-012-0259-3.
Imported Chagas disease (Trypanosoma cruzi infection) is increasingly recognized as an emerging problem in the USA and Europe due to immigration from Latin America. Most migrants from endemic countries will have been infected during childhood. Based on the natural history of the disease, up to 35 % of those infected may develop cardiac and/or gastrointestinal manifestations during the third or fourth decade of life. This disease was described more than 100 years ago, yet many challenges still remain such as the identification of risk factors for visceral involvement, effective treatment for chronic cases, and reliable markers of cure following treatment. Transmission of the infection may occur even in non-endemic areas through non-vectorial routes and many countries are therefore currently facing the challenge of this emerging public health problem.
原文：Imported Chagas disease (Trypanosoma cruzi infection) is increasingly recognized as an emerging problem in the USA and Europe due to immigration from Latin America. Most migrants from endemic countries will have been infected during childhood. Based on the natural history of the disease, up to 35 % of those infected may develop cardiac and/or gastrointestinal manifestations during the third or fourth decade of life. This disease was described more than 100 years ago, yet many challenges still remain such as the identification of risk factors for visceral involvement, effective treatment for chronic cases, and reliable markers of cure following treatment. Transmission of the infection may occur even in non-endemic areas through non-vectorial routes and many countries are therefore currently facing the challenge of this emerging public health problem.
译文：由于拉丁美洲移民，输入性恰加斯病（克氏锥虫感染）日益成为美国和欧洲的一个新出现的问题。大多数来自流行国家的移民在童年时期就已被感染。根据疾病的自然史，多达 35%的感染者可能在生命的第三或第四十年出现心脏和/或胃肠道表现。这种疾病在 100 多年前就有描述，但仍存在许多挑战，如内脏受累的风险因素的识别、慢性病例的有效治疗以及治疗后的可靠治愈标志物。即使在非流行地区，也可能通过非媒介途径传播感染，因此许多国家目前都面临着这一新兴公共卫生问题的挑战。
Zotero 插件