Department of Chemistry, University of Massachusetts Amherst, Massachusetts 01003, USA.
J Am Chem Soc. 2012 Apr 25;134(16):6964-7. doi: 10.1021/ja3019143. Epub 2012 Apr 11.
Supramolecular nanoassemblies, which are capable of binding and delivering either lipophilic small molecules or hydrophilic molecules, are of great interest. Concurrently binding and delivering this combination of molecules is cumbersome, because of the opposing supramolecular host requirements. We describe the development of a versatile nanoassembly system that is capable of binding and delivering both, a protein and a lipophilic small molecule, simultaneously inside the cells.
超分子纳米组装体能够结合并递送入孵小分子或亲水分子，这非常有趣。由于相反的超分子主体要求，同时结合和递送入孵这两种组合分子是繁琐的。我们描述了一种多功能纳米组装系统的开发，该系统能够在细胞内同时结合并递送入孵蛋白质和疏水分子。
