Villarreal José-Luis, Gutiérrez Jaime, Palacio Lucy, Peñuela Martha, Hernández Robin, Lemay Guy, Cervantes-Acosta Guillermo
Departamento de Medicina, Universidad del Norte, Barranquilla, Colombia.
AIDS Res Hum Retroviruses. 2012 Dec;28(12):1779-83. doi: 10.1089/AID.2011.0357. Epub 2012 May 21.
To characterize human immunodeficiency virus (HIV-1) strains circulating in the Northern region of Colombia in South America, sequences of the viral envelope C2V3C3 region were obtained from patients with different high-risk practices. Close to 60% of the sequences were predicted to belong to macrophage-tropic viruses, according to the positions of acidic amino acids and putative N-linked glycosylation sites. This is in agreement with the fact that most of the patients were recently diagnosed individuals. Phylogenic analysis then allowed assignment of all 35 samples to subtype B viruses. This same subtype was found in previous studies carried out in other Colombian regions. This study thus expands previous analyses with previously missing data from the Northern region of the country. The number and the length of the sequences examined also help to provide a clearer picture of the prevailing situation of the present HIV epidemics in this country.
为了鉴定在南美洲哥伦比亚北部地区传播的人类免疫缺陷病毒（HIV-1）毒株，从有不同高危行为的患者中获取了病毒包膜C2V3C3区域的序列。根据酸性氨基酸的位置和假定的N-连接糖基化位点，近60%的序列预计属于嗜巨噬细胞病毒。这与大多数患者是近期诊断出的个体这一事实相符。系统发育分析随后将所有35个样本归类为B亚型病毒。在哥伦比亚其他地区进行的先前研究中也发现了相同的亚型。因此，本研究用该国北部地区先前缺失的数据扩展了先前的分析。所检测序列的数量和长度也有助于更清楚地了解该国当前HIV流行的普遍情况。
