LLTech SAS, Paris, France.
Dermatology. 2012;224(1):84-92. doi: 10.1159/000337423. Epub 2012 Apr 6.
BACKGROUND/AIMS: Full-field optical coherence tomography (FFOCT) is a new imaging technology that can provide 3D micron-level resolution and is suited for high-resolution imaging of biological tissue. The aim of this study was to evaluate its capacity and potential for imaging human epidermis and dermis and various skin pathologies in ex vivo and in vivo conditions.
Non-fixed and fixed samples of normal and pathological skin and normal in vivo skin were imaged with a FFOCT system and compared to histological slides.
The epidermis and adnexae, the collagen bundles of the dermis and the hypodermis could be identified through architectural and cellular details. The pathological structures were distinguished from the normal structures and corresponded to their histopathological organization.
FFOCT is a novel technology in the field of skin imaging that has the potential to be a relevant complement to existing non-invasive imaging modalities for clinical and cosmetic applications.
背景/目的：全场光学相干断层扫描（FFOCT）是一种新的成像技术，可提供 3D 微米级分辨率，非常适合生物组织的高分辨率成像。本研究旨在评估其在体外和体内条件下对人表皮和真皮以及各种皮肤病变进行成像的能力和潜力。
使用 FFOCT 系统对正常和病理性皮肤的非固定和固定样本以及正常的活体皮肤进行成像，并与组织学切片进行比较。
通过结构和细胞细节，可以识别表皮和附属物、真皮的胶原束和皮下组织。病理性结构与正常结构区分开来，与它们的组织病理学结构相对应。
FFOCT 是皮肤成像领域的一项新技术，有可能成为临床和美容应用中现有非侵入性成像方式的重要补充。
