Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
J Nucl Med. 2012 May;53(5):673-6. doi: 10.2967/jnumed.111.099838. Epub 2012 Apr 9.
Despite significant advancements in medical and device-based therapies, cardiovascular disease remains the number one cause of death in the United States. Early detection of atherosclerosis, prevention of myocardial infarction and sudden cardiac death, and modulation of adverse ventricular remodeling still remain elusive goals. Molecular imaging focuses on identifying critical cellular and molecular targets and therefore plays an integral role in understanding these biologic processes in vivo. Because many imaging targets are upregulated before irreversible tissue damage occurs, early detection could ultimately lead to development of novel, preventive therapeutic strategies. This review addresses recent work on radionuclide imaging of cardiovascular inflammation, infection, and infarct healing. We further discuss opportunities provided by multimodality approaches such as PET/MRI and PET/optical imaging.
尽管在医学和器械治疗方面取得了重大进展，但心血管疾病仍是美国头号死亡原因。动脉粥样硬化的早期检测、心肌梗死和心脏性猝死的预防，以及对不良心室重构的调节仍然是难以实现的目标。分子成像专注于识别关键的细胞和分子靶标，因此在理解这些体内生物学过程中起着不可或缺的作用。由于许多成像靶标在发生不可逆转的组织损伤之前就已经上调，因此早期检测最终可能导致新的预防性治疗策略的发展。本综述讨论了心血管炎症、感染和梗死愈合的放射性核素成像的最新研究进展。我们还讨论了 PET/MRI 和 PET/光学成像等多模态方法所提供的机会。
