Department of Biological Regulation, Weizmann Institute of Science, 76100, Rehovot, Israel.
J Cardiovasc Transl Res. 2011 Aug;4(4):477-92. doi: 10.1007/s12265-011-9275-1. Epub 2011 Mar 31.
Cardiac magnetic resonance imaging (CMR) has become a reference standard modality for imaging of left ventricular (LV) structure and function and, using late gadolinium enhancement, for imaging myocardial infarction. Emerging CMR techniques enable a more comprehensive examination of the heart, making CMR an excellent tool for use in translational cardiovascular research. Specifically, emerging CMR methods have been developed to measure the extent of myocardial edema, changes in ventricular mechanics, changes in tissue composition as a result of fibrosis, and changes in myocardial perfusion as a function of both disease and infarct healing. New CMR techniques also enable the tracking of labeled cells, molecular imaging of biomarkers of disease, and changes in calcium flux in cardiomyocytes. In addition, MRI can quantify blood flow velocity and wall shear stress in large blood vessels. Almost all of these techniques can be applied in both pre-clinical and clinical settings, enabling both the techniques themselves and the knowledge gained using such techniques in pre-clinical research to be translated from the lab bench to the patient bedside.
心脏磁共振成像（CMR）已成为左心室（LV）结构和功能成像的参考标准模式，并且可以使用晚期钆增强成像来诊断心肌梗死。新兴的 CMR 技术能够更全面地检查心脏，使 CMR 成为转化心血管研究的绝佳工具。具体来说，新兴的 CMR 方法已被开发用于测量心肌水肿的程度、心室力学的变化、纤维化导致的组织成分变化以及心肌灌注随疾病和梗塞愈合的变化。新的 CMR 技术还可以跟踪标记细胞、疾病生物标志物的分子成像以及心肌细胞中钙通量的变化。此外，MRI 可以定量大动脉中的血流速度和壁面切应力。几乎所有这些技术都可以在临床前和临床环境中应用，从而使这些技术本身以及使用此类技术在临床前研究中获得的知识，都能够从实验室转化为患者床边。
