Department of Food Science and Biotechnology, College of Engineering, Gachon University, Sungnam-Si, Kyunggi-Do, South Korea.
J Virol. 2012 May;86(9):5402-3. doi: 10.1128/JVI.00321-12.
Enterococcus faecalis is an important bacterium for use as a probiotic and is an opportunistic pathogen in human beings. The antibiotic resistance acquired by E. faecalis is restricted to antibiotics used in the clinical setting. While screening for alternative antibiotics for use against multidrug-resistant E. faecalis, we isolated a virulent enterococcal bacteriophage, SAP6, belonging to the family Siphoviridae. To our knowledge, this study is the first to report the complete genome sequence of bacteriophage SAP6, which might be used as a therapeutic agent in combination with alternative antibiotics for multidrug-resistant E. faecalis.
屎肠球菌是一种重要的益生菌，也是人类中的机会致病菌。屎肠球菌获得的抗生素耐药性仅限于临床应用的抗生素。在筛选针对多药耐药屎肠球菌的替代抗生素时，我们分离到一种烈性肠球菌噬菌体 SAP6，属于肌尾噬菌体科。据我们所知，这项研究首次报道了噬菌体 SAP6 的完整基因组序列，它可能与替代抗生素联合用于治疗多药耐药屎肠球菌。
