Department of Oral Pathology, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
Anticancer Res. 2012 Apr;32(4):1515-25.
Ameloblastic carcinoma (AC) is a rare malignant odontogenic neoplasm with scarce reported cases in the literature and it can be confused with benign ameloblastoma (AM). This study reports a case of AC, and presents a literature review of AC classified into primary type (ACPt) or secondary type (ACSt) by the World Health Organization (WHO). The review addressed 31 cases published in the English literature between the years 2005 and 2011. The majority of cases were ACSt. The mandible was the most common site of occurrence for both AC types. All patients who died of their disease had ACSt. Tumors with plexiform pattern, hyperchromatism, mitosis and necrosis were associated with a higher ratio of histories of recurrence and death by disease, as well as the tumors with clear cells, especially in the ACSt. ACSt appeared to correlate with recurrence and mortality. The histological features may have different prognostic importance depending on the AC type.
成釉细胞瘤（AC）是一种罕见的恶性牙源性肿瘤，文献中报道的病例较少，容易与良性成釉细胞瘤（AM）混淆。本研究报告了 1 例 AC，并对世界卫生组织（WHO）分类为原发性（ACPt）或继发性（ACSt）的 AC 进行文献复习。该综述共纳入 2005 年至 2011 年期间发表在英文文献中的 31 例病例。大多数病例为 ACSt。两种类型的 AC 最常见的发病部位均为下颌骨。所有死于该病的患者均为 ACSt。具有丛状模式、嗜色性、有丝分裂和坏死的肿瘤与较高的复发和死亡比以及具有透明细胞的肿瘤，特别是在 ACSt 中相关。ACSt 似乎与复发和死亡率相关。组织学特征可能因 AC 类型而异，具有不同的预后意义。
