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原肌球蛋白的弯曲刚度和单个Ca(2+)调节单元动力学：对心肌收缩和心肌细胞肥大协同调节的影响。

Tropomyosin flexural rigidity and single ca(2+) regulatory unit dynamics: implications for cooperative regulation of cardiac muscle contraction and cardiomyocyte hypertrophy.

作者信息

Loong Campion K P, Badr Myriam A, Chase P Bryant

机构信息

Department of Biological Science, The Florida State University Tallahassee, FL, USA.

出版信息

Front Physiol. 2012 Apr 4;3:80. doi: 10.3389/fphys.2012.00080. eCollection 2012.

DOI:10.3389/fphys.2012.00080
PMID:22493584
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3318232/
Abstract

Striated muscle contraction is regulated by dynamic and cooperative interactions among Ca(2+), troponin, and tropomyosin on the thin filament. While Ca(2+) regulation has been extensively studied, little is known about the dynamics of individual regulatory units and structural changes of individual tropomyosin molecules in relation to their mechanical properties, and how these factors are altered by cardiomyopathy mutations in the Ca(2+) regulatory proteins. In this hypothesis paper, we explore how various experimental and analytical approaches could broaden our understanding of the cooperative regulation of cardiac contraction in health and disease.

摘要

横纹肌收缩受细肌丝上钙离子、肌钙蛋白和原肌球蛋白之间动态协同相互作用的调节。虽然钙离子调节已得到广泛研究，但对于单个调节单元的动力学以及单个原肌球蛋白分子与其力学性质相关的结构变化，以及这些因素如何因钙离子调节蛋白中的心肌病突变而改变，我们知之甚少。在这篇假说论文中，我们探讨了各种实验和分析方法如何能拓宽我们对健康和疾病状态下心脏收缩协同调节的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14ff/3318232/5fa80793afb0/fphys-03-00080-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14ff/3318232/84fe6156a6ef/fphys-03-00080-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14ff/3318232/e68a66b43c7e/fphys-03-00080-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14ff/3318232/f729a9ebdef1/fphys-03-00080-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14ff/3318232/0a00609b8f42/fphys-03-00080-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14ff/3318232/5fa80793afb0/fphys-03-00080-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14ff/3318232/84fe6156a6ef/fphys-03-00080-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14ff/3318232/e68a66b43c7e/fphys-03-00080-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14ff/3318232/f729a9ebdef1/fphys-03-00080-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14ff/3318232/0a00609b8f42/fphys-03-00080-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14ff/3318232/5fa80793afb0/fphys-03-00080-g005.jpg

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