Comprehensive Gynecological Cancer Center, CHA Bundang Medical Center, CHA University, College of Medicine, Bundang, South Korea.
Virol J. 2012 Apr 12;9:80. doi: 10.1186/1743-422X-9-80.
In contrast to consistent epidemiologic evidence of the role of sexual transmission of human papillomavirus (HPV) in adults, various routes may be related to HPV infection in infants. We have assessed the extent of HPV infection during the perinatal period, and the relationship between mode of delivery and vertical transmission.
A total of 291 pregnant women over 36 weeks of gestation were enrolled with informed consent. Exfoliative cells were collected from maternal cervix and neonatal buccal mucosa. HPV infection and genotypes were determined with an HPV DNA chip, which can recognise 24 types. The HPV-positive neonates were re-evaluated 6 months after birth to identify the presence of persistent infection. HPV DNA was detected in 18.9 % (55/291) of pregnant women and 3.4 % (10/291) of neonates. Maternal infection was associated with abnormal cytology (p = 0.007) and primiparity (p = 0.015). The infected neonates were all born to HPV-positive mothers. The rate of vertical transmission was estimated at 18.2 % (10/55) which was positively correlated with maternal multiple HPV infection (p = 0.003) and vaginal delivery (p = 0.050), but not with labour duration and premature rupture of membranes. The rate of concordance of genotype was 100 % in mother-neonate pairs with vertical transmission. The neonatal HPV DNAs found at birth were all cleared at 6 months after delivery.
Vertical transmission of HPV DNA from HPV infected mother to the neonate increased when the infant was delivered through an infected cervix. However, the absence of persistent infection in infants at 6 months after delivery may suggest temporary inoculation rather than true vertical infection.
尽管有一致的流行病学证据表明人乳头瘤病毒（HPV）在成人中的性传播作用，但各种途径可能与婴儿的 HPV 感染有关。我们评估了围产期 HPV 感染的程度，以及分娩方式与垂直传播之间的关系。
共有 291 名妊娠超过 36 周的孕妇签署知情同意书后参与了研究。采集母体宫颈和新生儿口腔黏膜的脱落细胞。使用 HPV DNA 芯片检测 HPV 感染和基因型，该芯片可识别 24 种类型。对 HPV 阳性的新生儿在出生后 6 个月进行重新评估，以确定是否存在持续性感染。在 291 名孕妇中有 18.9%（55/291）和 3.4%（10/291）的孕妇和新生儿 HPV DNA 阳性。母体感染与细胞学异常（p=0.007）和初产妇（p=0.015）有关。感染的新生儿均来自 HPV 阳性的母亲。垂直传播率估计为 18.2%（10/55），与母体多重 HPV 感染（p=0.003）和阴道分娩（p=0.050）呈正相关，但与产程和胎膜早破无关。垂直传播的母婴 HPV 基因型一致性率为 100%。出生时发现的新生儿 HPV DNA 均在出生后 6 个月清除。
当婴儿经感染的宫颈分娩时，来自 HPV 感染母亲的 HPV DNA 垂直传播增加。然而，在出生后 6 个月时婴儿没有持续性感染，这可能表明是暂时接种，而不是真正的垂直感染。
