药物依从性与多药治疗方案。
Medication adherence to multidrug regimens.
机构信息
Department of Medicine (Geriatrics), School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
出版信息
Clin Geriatr Med. 2012 May;28(2):287-300. doi: 10.1016/j.cger.2012.01.008.
Abstract
Despite the fact that medication adherence has been extensively described in the literature over the last several decades, a quote by Becker and Maiman from over 35 years ago best captures the current state of our understanding: “Patient compliance[sic adherence] has become the best documented, but least understood, health behavior.” Future research is greatly needed to identify and translate safe and effective interventions into routine clinical practice to improve adherence. Only then can we begin to make significant improvements to the medication use process and, in turn, the health of older adults.
摘要
尽管在过去几十年中，文献中已经广泛描述了药物依从性，但 Becker 和 Maiman 三十多年前的一句话最能准确描述我们目前对这一问题的理解：“患者的遵医嘱[即依从性]已经成为记录最完善，但理解最少的健康行为。”未来的研究非常有必要，以确定并将安全有效的干预措施转化为常规临床实践，从而提高依从性。只有这样，我们才能开始对药物使用过程进行重大改进，并最终改善老年人的健康状况。
相似文献
1
Medication adherence to multidrug regimens.药物依从性与多药治疗方案。
Clin Geriatr Med. 2012 May;28(2):287-300. doi: 10.1016/j.cger.2012.01.008.
2
Non-adherence to medication regimens among older African-American adults.非裔美国老年人中不坚持药物治疗方案的情况。
BMC Geriatr. 2017 Jul 25;17(1):163. doi: 10.1186/s12877-017-0558-5.
3
Theory-Based Interventions to Improve Medication Adherence in Older Adults Prescribed Polypharmacy: A Systematic Review.基于理论的干预措施以提高老年多重用药患者的药物依从性：一项系统评价
Drugs Aging. 2017 Feb;34(2):97-113. doi: 10.1007/s40266-016-0426-6.
4
Nurse interventions to improve medication adherence among discharged older adults: a systematic review.护士干预措施以提高出院老年患者的药物依从性：系统评价。
Age Ageing. 2017 Sep 1;46(5):747-754. doi: 10.1093/ageing/afx076.
5
A Portal-Based Intervention (PATTERN) Designed to Support Medication Use Among Older Adults: Feasibility and Acceptability Study.一项旨在支持老年人用药的基于门户网站的干预措施（PATTERN）：可行性和可接受性研究。
JMIR Form Res. 2025 Apr 24;9:e71676. doi: 10.2196/71676.
6
Medication beliefs and self-reported adherence among community-dwelling older adults.社区居住的老年人群体的用药信念和自我报告的用药依从性。
Clin Ther. 2013 Feb;35(2):153-60. doi: 10.1016/j.clinthera.2013.01.001. Epub 2013 Jan 26.
7
Medication adherence and knowledge of older patients with and without multidose drug dispensing.多剂量药物配给的老年患者和无多剂量药物配给的老年患者的药物依从性和知识水平。
Age Ageing. 2013 Sep;42(5):620-6. doi: 10.1093/ageing/aft083. Epub 2013 Jul 5.
8
Effectiveness of Electronic Medication Packaging Devices on Medication Adherence: A Scoping Review.电子药物包装设备对药物依从性的影响：系统评价。
J Gerontol Nurs. 2020 Mar 1;46(3):27-36. doi: 10.3928/00989134-20200129-01.
9
Medication Regimen Complexity and Low Adherence in Older Community-Dwelling Adults With Substantiated Self-Neglect.有实证自我忽视的老年社区居住成年人的药物治疗方案复杂性和低遵从性。
J Appl Gerontol. 2019 Jun;38(6):866-883. doi: 10.1177/0733464817714565. Epub 2017 Jun 23.
10
Differential Diagnoses and Clinical Implications of Medication Nonadherence in Older Patients with Chronic Kidney Disease: A Review.老年慢性肾脏病患者药物治疗不依从的鉴别诊断及临床意义：综述
Drugs Aging. 2020 Dec;37(12):875-884. doi: 10.1007/s40266-020-00804-8. Epub 2020 Oct 8.
引用本文的文献
1
Practical limitations of complex insulin therapies in type 2 diabetes: Focus on therapy simplification using fixed-ratio combinations of basal insulin and a glucagon-like peptide-1 receptor agonist.2型糖尿病复杂胰岛素治疗的实际局限性：聚焦于使用基础胰岛素与胰高血糖素样肽-1受体激动剂的固定比例组合简化治疗方案
Diabetes Obes Metab. 2025 Aug;27 Suppl 7:42-54. doi: 10.1111/dom.16645. Epub 2025 Jul 28.
2
Evaluating the efficacy of blister packaging in improving medication adherence within psychiatry: A systematic literature review.评估泡罩包装在提高精神科药物依从性方面的疗效：一项系统文献综述。
Ment Health Clin. 2025 Jun 2;15(3):176-186. doi: 10.9740/mhc.2025.06.176. eCollection 2025 Jun.
3
Dual effects of and on hyperglycemia and infection in .[具体物质]和[具体物质]对[具体病症]中高血糖和感染的双重影响。
Narra J. 2025 Apr;5(1):e1972. doi: 10.52225/narra.v5i1.1972. Epub 2024 Feb 12.
4
Increased Myocardial Expression in Patients with Heart Failure and Sleep-Disordered Breathing.心力衰竭和睡眠呼吸障碍患者心肌表达增加。
Int J Mol Sci. 2025 Apr 11;26(8):3614. doi: 10.3390/ijms26083614.
5
Starting Two or More Drugs Concurrently in Primary Care: How Often Is It Done, How Often Is It Needed?在基层医疗中同时开始使用两种或更多药物：这样做的频率如何，需求频率又如何？
J Gen Intern Med. 2025 Mar 28. doi: 10.1007/s11606-025-09455-0.
6
Barriers to Implementing Effective Healthcare Practices for the Aging Population: Approaches to Identification and Management.实施针对老年人群的有效医疗保健措施的障碍：识别与管理方法
Cureus. 2025 Feb 24;17(2):e79590. doi: 10.7759/cureus.79590. eCollection 2025 Feb.
7
Myocardial Expression Is Increased in Patients with Impaired Cardiac Contractility and Sleep-Disordered Breathing.心肌表达在心脏收缩功能受损和睡眠呼吸紊乱患者中增加。
Antioxidants (Basel). 2025 Jan 29;14(2):163. doi: 10.3390/antiox14020163.
8
Prevalence of adherence and its impact on quality of life in oral anticoagulant users in Egypt: A cross-sectional study from two Egyptian university hospitals.埃及口服抗凝剂使用者的依从性患病率及其对生活质量的影响：来自两家埃及大学医院的横断面研究。
BMC Cardiovasc Disord. 2025 Feb 8;25(1):88. doi: 10.1186/s12872-024-04341-9.
9
Exploring Drug-Drug Interactions between Losartan and Carbamazepine: A Pharmacokinetic and Pharmacodynamic Study.探索氯沙坦与卡马西平之间的药物相互作用：一项药代动力学和药效学研究。
Curr Drug Metab. 2024;25(9):685-694. doi: 10.2174/0113892002358068250119052940.
10
Factors Influencing Medication Adherence in Heart Failure Patients-A Survey Among Cardiac Healthcare Providers.影响心力衰竭患者药物依从性的因素——心脏医疗服务提供者的一项调查
Clin Pharmacol Ther. 2025 Apr;117(4):1088-1097. doi: 10.1002/cpt.3526. Epub 2024 Dec 18.
本文引用的文献
1
Reminder packaging for improving adherence to self-administered long-term medications.用于提高长期自我给药依从性的提醒包装。
Cochrane Database Syst Rev. 2011 Sep 7(9):CD005025. doi: 10.1002/14651858.CD005025.pub3.
2
Importance of including early nonadherence in estimations of medication adherence.重视将早期不依从纳入药物依从性的估计中。
Ann Pharmacother. 2011 Sep;45(9):1053-60. doi: 10.1345/aph.1Q146. Epub 2011 Aug 18.
3
Principles of conservative prescribing.保守用药原则。
Arch Intern Med. 2011 Sep 12;171(16):1433-40. doi: 10.1001/archinternmed.2011.256. Epub 2011 Jun 13.
4
The implications of therapeutic complexity on adherence to cardiovascular medications.治疗复杂性对心血管药物依从性的影响。
Arch Intern Med. 2011 May 9;171(9):814-22. doi: 10.1001/archinternmed.2010.495.
5
A systematic review of barriers to medication adherence in the elderly: looking beyond cost and regimen complexity.老年人药物依从性障碍的系统评价：超越成本和治疗方案复杂性
Am J Geriatr Pharmacother. 2011 Feb;9(1):11-23. doi: 10.1016/j.amjopharm.2011.02.004.
6
Improving the measurement of self-reported medication nonadherence.提高自我报告药物治疗不依从性的测量。
J Clin Epidemiol. 2011 Mar;64(3):250-4. doi: 10.1016/j.jclinepi.2010.07.014. Epub 2010 Dec 30.
7
Copayment reductions generate greater medication adherence in targeted patients.自付额降低可提高目标患者的药物依从性。
Health Aff (Millwood). 2010 Nov;29(11):2002-8. doi: 10.1377/hlthaff.2010.0571.
8
Managing medications in clinically complex elders: "There's got to be a happy medium".管理临床情况复杂的老年人的药物：“需要找到一个平衡点”。
JAMA. 2010 Oct 13;304(14):1592-601. doi: 10.1001/jama.2010.1482.
9
Feasibility study of a systematic approach for discontinuation of multiple medications in older adults: addressing polypharmacy.老年人停用多种药物的系统方法的可行性研究：解决多重用药问题
Arch Intern Med. 2010 Oct 11;170(18):1648-54. doi: 10.1001/archinternmed.2010.355.
10
Predictors of very low adherence with medications for osteoporosis: towards development of a clinical prediction rule.骨质疏松症药物极低依从性的预测因素：制定临床预测规则。
Osteoporos Int. 2011 Jun;22(6):1737-43. doi: 10.1007/s00198-010-1381-4. Epub 2010 Sep 29.
Zotero 插件