Slots J, Feik D, Rams T E
University of Pennsylvania, School of Dental Medicine, Department of Periodontics, Philadelphia, PA 19104.
J Clin Periodontol. 1990 Oct;17(9):659-62.
This study examined age relationships and mutual interrelationships between cultivable Actinobacillus actinomycetemcomitans and Bacteroides intermedius in 1624 periodontitis patients, 15 to 89 years of age. Each subject contributed a pooled subgingival sample, obtained from 3 deep periodontal pockets with paper points. A. actinomycetemcomitans occurred with higher prevalence (74%) and mean recovery (7% in culture-positive patients) in patients less than 25 years old than in adult and geriatric patients (prevalence about 31%; mean recovery about 1%). The organism was detected in 85% of localized juvenile periodontitis patients. B. intermedius was recovered from 45% of the study subjects, averaged about 7% of total isolates in positive patients, and showed no predilection for any age group. As determined from predicted and observed values for A. actinomycetemcomitans and B. intermedius, occurring alone and in combination, no synergistic or antagonistic relationships between the organisms could be delineated with respect to subgingival colonization. The therapeutic implication of these findings is discussed.
本研究调查了1624例年龄在15至89岁之间的牙周炎患者中可培养的伴放线放线杆菌与中间普氏菌之间的年龄关系及相互关系。每位受试者提供一份龈下混合样本，该样本通过纸尖从3个深牙周袋中获取。与成年和老年患者相比（患病率约为31%；平均回收率约为1%），伴放线放线杆菌在25岁以下患者中的患病率更高（74%），平均回收率也更高（培养阳性患者中为7%）。在85%的局限性青少年牙周炎患者中检测到了该菌。45%的研究对象分离出了中间普氏菌，在阳性患者中其平均占总分离菌的7%左右，且在各年龄组中均无偏好。根据伴放线放线杆菌和中间普氏菌单独及联合出现的预测值和观察值，就龈下定植而言，无法确定这两种菌之间存在协同或拮抗关系。本文讨论了这些发现的治疗意义。
