Rodenburg J P, van Winkelhoff A J, Winkel E G, Goené R J, Abbas F, de Graff J
Clinic for Periodontology Amsterdam, The Netherlands.
J Clin Periodontol. 1990 Jul;17(6):392-9. doi: 10.1111/j.1600-051x.1990.tb00036.x.
A total of 242 subjects including 138 untreated severe periodontitis patients and 104 patients with refractory periodontal disease, previously treated for severe periodontitis, were examined for the occurrence of Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius. Pooled subgingival samples of representative periodontal lesions were used for anaerobic cultivation on blood agar and for the enumeration of A. actinomycetemcomitans on selective TSBV medium. 97% of the untreated patients were infected with one or more of the test micro-organisms. In this patient group, the occurrence of A. actinomycetemcomitans, B. gingivalis and B. intermedius was 54%, 48% and 63%, respectively. The prevalence of A. actinomycetemcomitans positive patients appeared to be age related and decreased with increasing age. Likewise, the number of patients solely infected with A. actinomycetemcomitans decreased with increasing age. The prevalence of B. gingivalis infected patients appeared to increase with increasing age. These phenomena were not observed in the refractory periodontitis patients. The occurrence of A. actinomycetemcomitans, B. gingivalis and B. intermedius in the refractory periodontitis group was 55%, 27% and 59%, respectively. A statistical significant difference in the prevalence of B. gingivalis was found between the untreated and the refractory periodontitis patients. In both patient groups, the relative proportion of A. actinomycetemcomitans was significantly higher in subjects with this bacterium as the sole indicator micro-organism than in patients who, besides being infected with A. actinomycetemcomitans, were also infected with black-pigmented Bacteroides species. Furthermore, in comparison with untreated patients, unsuccessfully treated patients solely infected with A. actinomycetemcomitans had on average a lower number but also a higher mean % of this bacterium.(ABSTRACT TRUNCATED AT 250 WORDS)
共对242名受试者进行了检查，其中包括138名未经治疗的重度牙周炎患者和104名曾因重度牙周炎接受过治疗的顽固性牙周病患者，检测伴放线放线杆菌、牙龈拟杆菌和中间普氏菌的感染情况。采集具有代表性的牙周病变部位的龈下样本，用于在血琼脂上进行厌氧培养，并在选择性TSBV培养基上对伴放线放线杆菌进行计数。97%的未经治疗的患者感染了一种或多种检测微生物。在该患者组中，伴放线放线杆菌、牙龈拟杆菌和中间普氏菌的感染率分别为54%、48%和63%。伴放线放线杆菌阳性患者的患病率似乎与年龄相关，且随年龄增长而降低。同样，仅感染伴放线放线杆菌的患者数量也随年龄增长而减少。牙龈拟杆菌感染患者的患病率似乎随年龄增长而增加。在顽固性牙周炎患者中未观察到这些现象。顽固性牙周炎组中伴放线放线杆菌、牙龈拟杆菌和中间普氏菌的感染率分别为55%、27%和59%。在未经治疗的患者和顽固性牙周炎患者之间，牙龈拟杆菌的患病率存在统计学显著差异。在两个患者组中，以伴放线放线杆菌作为唯一指示微生物的受试者中，该菌的相对比例显著高于除感染伴放线放线杆菌外还感染了产黑色素拟杆菌属菌种的患者。此外，与未经治疗的患者相比，仅感染伴放线放线杆菌且治疗失败的患者，该菌的平均数量较低，但平均百分比更高。（摘要截选至250词）
