Aarsland A, Lundquist M, Børretsen B, Berge R K
Laboratory of Clinical Biochemistry, University of Bergen, Norway.
Lipids. 1990 Sep;25(9):546-8. doi: 10.1007/BF02537162.
Repeated administration of highly purified eicosapentaenoic acid (as ethyl ester) resulted in a decrease in plasma triglycerides and high density lipoprotein (HDL) cholesterol. This was accompanied by a stimulation in the activities of carnitine palmitoyltransferase, fatty acyl-CoA oxidase and peroxisomal beta-oxidation in the liver. The results suggest that the triglyceride-lowering effect observed with eicosapentaenoic acid may be due to a reduced supply of fatty acids for hepatic triglyceride synthesis because of increased fatty acid oxidation. Eicosapentaenoic acid feeding marginally affected the triglyceride content of heart and mitochondrial and peroxisomal enzyme activities.
重复给予高纯度二十碳五烯酸（乙酯形式）会导致血浆甘油三酯和高密度脂蛋白（HDL）胆固醇水平降低。同时，肝脏中的肉碱棕榈酰转移酶、脂肪酰辅酶A氧化酶活性以及过氧化物酶体β氧化作用受到刺激。结果表明，二十碳五烯酸所观察到的降甘油三酯作用可能是由于脂肪酸氧化增加，减少了用于肝脏甘油三酯合成的脂肪酸供应。给予二十碳五烯酸对心脏的甘油三酯含量以及线粒体和过氧化物酶体酶活性影响较小。
