Leeds Vascular Institute, The General Infirmary at Leeds, Great George Street, Leeds, UK.
Eur J Vasc Endovasc Surg. 2012 Jun;43(6):721-5. doi: 10.1016/j.ejvs.2012.02.026. Epub 2012 Apr 15.
To compare the half-life of STD and polidocanol air-based foams and the damage they inflict upon human great saphenous vein in an in-vitro model.
The time for the volume of 3% STD and polidocanol foams to reduce by 10% (T(90)) and 50% (T(50)) was recorded in an incubator at 37 °C. Segments of proximal GSV harvested during varicose vein surgery were filled with foam for 5 or 15 min. Histological analysis determined percentage endothelial cell loss and depth of media injury.
Median (±IQR) T(90) and T(50) for polidocanol were 123.3 s (111.7-165.6) and 266.3 s (245.6-383.1) versus 102.03 s (91.1-112) and 213.13 s (201-231.6) for STD (T(90)p = 0.008, T(50)p = 0.004). Median endothelial loss with polidocanol was; 63.5% (62.2-82.8) and 85.9% (83.8-92.5) versus 86.3% (84.8-93.7) and 97.64% (97.3-97.8) for STD after 5 and 15 min (p = 0.076 and p = 0.009). The median depth and % media thickness injured were 0 μm (0-0 μm) and 0% for both assessments with polidocanol versus 37.4 μm (35.3-45.8 and 43.4 μm (42.1-46.7) and 3.5% (3.1-3.6) and 5.3% (3.7-6.0) after 5 and 15 min for STD (p < 0.01 for all comparisons).
Although polidocanol foam shows greater stability than STD foam perhaps remaining in the vein for longer, endothelial cell loss and damage to the media were significantly greater with STD.
比较 STD 和聚多卡醇空气泡沫在体外模型中对人隐股静脉的半衰期和损伤。
在 37°C 的孵育箱中记录 3% STD 和聚多卡醇泡沫体积减少 10%（T(90)）和 50%（T(50)）所需的时间。在静脉曲张手术中采集的近端 GSV 段用泡沫填充 5 或 15 分钟。组织学分析确定内皮细胞丧失百分比和中膜损伤深度。
聚多卡醇的中位数（±IQR）T(90)和 T(50)分别为 123.3 秒（111.7-165.6）和 266.3 秒（245.6-383.1），而 STD 分别为 102.03 秒（91.1-112）和 213.13 秒（201-231.6）（T(90)p = 0.008，T(50)p = 0.004）。聚多卡醇的中位内皮细胞丢失率分别为：63.5%（62.2-82.8）和 85.9%（83.8-92.5），而 STD 分别为 86.3%（84.8-93.7）和 97.64%（97.3-97.8），5 分钟和 15 分钟后（p = 0.076 和 p = 0.009）。聚多卡醇的中位损伤深度和中膜厚度百分比分别为 0μm（0-0μm）和 0%，而 STD 分别为 37.4μm（35.3-45.8）和 43.4μm（42.1-46.7）和 3.5%（3.1-3.6）和 5.3%（3.7-6.0），5 分钟和 15 分钟后（所有比较均 p < 0.01）。
尽管聚多卡醇泡沫的稳定性大于 STD 泡沫，可能在静脉中停留时间更长，但 STD 泡沫导致的内皮细胞丢失和中膜损伤明显更大。
