The Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, 987696 Nebraska Medical Center, Omaha, NE 68198, USA.
Nat Rev Gastroenterol Hepatol. 2012 Apr 17;9(6):334-44. doi: 10.1038/nrgastro.2012.63.
Advances in understanding the biology of tumour progression and metastasis have clearly highlighted the importance of aberrant tumour metabolism, which supports not only the energy requirements but also the enormous biosynthetic needs of tumour cells. Such metabolic alterations modulate glucose, amino acid and fatty-acid-dependent metabolite biosynthesis and energy production. Although much progress has been made in understanding the somatic mutations and expression genomics behind these alterations, the regulation of these processes by microRNAs (miRNAs) is only just beginning to be appreciated. This Review focuses on the miRNAs that are potential regulators of the expression of genes whose protein products either directly regulate metabolic machinery or serve as master regulators, indirectly modulating the expression of metabolic enzymes. We focus particularly on miRNAs in pancreatic cancer.
肿瘤进展和转移生物学研究的进展清楚地强调了肿瘤代谢异常的重要性，它不仅支持肿瘤细胞的能量需求，还支持其巨大的生物合成需求。这些代谢改变调节葡萄糖、氨基酸和脂肪酸依赖性代谢物的生物合成和能量产生。尽管在理解这些改变背后的体细胞突变和表达组学方面已经取得了很大进展，但 miRNA（microRNA）对这些过程的调节才刚刚开始被认识。这篇综述的重点是那些可能调节基因表达的 miRNA，这些基因的蛋白质产物直接调节代谢机制或作为主调控因子，间接调节代谢酶的表达。我们特别关注胰腺癌中的 miRNA。
