Unité de Recherche en Épidémiologie Systèmes d'Information et Modélisation U707, Institut national de la santé et de la recherche médicale, Paris, France.
PLoS One. 2012;7(4):e34387. doi: 10.1371/journal.pone.0034387. Epub 2012 Apr 11.
Although increasing numbers of very elderly patients are requiring intensive care, few large sample studies have investigated ICU admission of very elderly patients. Data on pre triage by physicians from other specialities is limited. This observational cohort study aims at examining inter-hospital variability of ICU admission rates and its association with patients' outcomes. All patients over 80 years possibly qualifying for ICU admission who presented to the emergency departments (ED) of 15 hospitals in the Paris (France) area during a one-year period were prospectively included in the study. Main outcome measures were ICU eligibility, as assessed by the ED and ICU physicians; in-hospital mortality; and vital and functional status 6 months after the ED visit. 2646 patients (median age 86; interquartile range 83-91) were included in the study. 94% of participants completed follow-up (n = 2495). 12.4% (n = 329) of participants were deemed eligible for ICU admission by ED physicians and intensivists. The overall in-hospital and 6-month mortality rates were respectively 27.2% (n = 717) and 50.7% (n = 1264). At six months, 57.5% (n = 1433) of patients had died or had a functional deterioration. Rates of patients deemed eligible for ICU admission ranged from 5.6% to 38.8% across the participating centers, and this variability persisted after adjustment for patients' characteristics. Despite this variability, we found no association between level of ICU eligibility and either in-hospital death or six-month death or functional deterioration. In France, the likelihood that a very elderly person will be admitted to an ICU varies widely from one hospital to another. Influence of intensive care admission on patients' outcome remains unclear.
ClinicalTrials.gov NCT00912600.
本观察性队列研究旨在调查 ICU 收治超高龄患者的比例在各医院间的差异,并分析其与患者预后的相关性。
在为期 1 年期间,所有可能符合 ICU 收治标准的 80 岁以上患者在法国巴黎地区的 15 家医院急诊科就诊,前瞻性地将其纳入本研究。主要观察指标为急诊科和 ICU 医生评估的 ICU 收治条件;院内死亡率;以及急诊科就诊后 6 个月的存活和功能状态。
共纳入 2646 例患者(中位年龄 86 岁,四分位间距 8391 岁)。94%(n=2495)的患者完成了随访。急诊科医生和重症医生认为 12.4%(n=329)的患者符合 ICU 收治条件。总的院内和 6 个月死亡率分别为 27.2%(n=717)和 50.7%(n=1264)。6 个月时,57.5%(n=1433)的患者死亡或功能恶化。纳入 ICU 的患者比例在各参与中心间的差异为 5.6%38.8%,且这种差异在调整患者特征后仍然存在。尽管存在这种差异,但我们并未发现 ICU 收治条件与院内死亡、6 个月死亡或功能恶化之间存在关联。
在法国,超高龄患者入住 ICU 的可能性在各医院间差异较大。入住 ICU 对患者预后的影响仍不清楚。
ClinicalTrials.gov,NCT00912600。