Laboratorio de Microbiologia e Bioquimica Aplicada, Instituto de Ciencia e Tecnologia de Alimentos, Universidade Federal do Rio Grande do Sul, Av. Bento Goncalves 9500, 91501-970 Porto Alegre, Brazil.
Mini Rev Med Chem. 2012 Jul;12(8):731-41. doi: 10.2174/138955712801264774.
Antimicrobial peptides have been extensively investigated for their potential applications as therapeutics and food biopreservatives. The antimicrobial activity may be impaired by the susceptibility for proteolytic degradation and undesirable interactions of the antimicrobial peptide in the biological environment. Development of nanostructures for entrapment and delivery of antimicrobial peptides may represent an alternative to the direct application of these substances. Lipid nanovesicles have been developed for encapsulation of antimicrobial peptides. Phosphatidylcholine is often employed in liposome manufacture, which is mostly achieved by the thin-film hydration method. Nanofibers may allow different physical modes of drug loading, including direct adsorption on the nanofiber surface or the assembly of drug-loaded nanoparticles. Self-assembled peptides reveal attractive features as nanostructures for applications in drug delivery and promising as antimicrobial agent for treatment of brain infections. Magnetic nanoparticles and nanotubules are also potential structures for entrapment of antimicrobial peptides. Nanoparticles can be also chemically modified with specific cell surface ligands to enhance cell adhesion and site specific delivery. This article reviews the most important nanostructures as promising tools for peptide delivery systems.
抗菌肽因其作为治疗剂和食品生物防腐剂的潜在应用而受到广泛研究。抗菌肽在生物环境中易受蛋白水解降解和不良相互作用的影响，其抗菌活性可能会受到损害。开发用于包封和输送抗菌肽的纳米结构可能是直接应用这些物质的替代方法。脂质纳米囊泡已被开发用于包封抗菌肽。磷脂酰胆碱常用于制造脂质体，主要通过薄膜水化法实现。纳米纤维可以允许不同的物理药物加载模式，包括直接吸附在纳米纤维表面或装载药物的纳米颗粒的组装。自组装肽作为药物输送的纳米结构具有吸引力，并且作为治疗脑部感染的抗菌剂有很大的应用前景。磁性纳米颗粒和纳米管也是包封抗菌肽的潜在结构。纳米颗粒也可以用特定的细胞表面配体进行化学修饰，以增强细胞黏附和靶向递药。本文综述了最重要的纳米结构，它们是有前途的肽递药系统工具。
