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中枢神经系统中纳米材料的治疗学、成像和毒性。

Therapeutics, imaging and toxicity of nanomaterials in the central nervous system.

机构信息

Nanomedicine Laboratory, Centre for Drug Delivery Research, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.

出版信息

J Control Release. 2012 Jul 20;161(2):290-306. doi: 10.1016/j.jconrel.2012.03.026. Epub 2012 Apr 4.

Abstract

Treatment and diagnosis of neurodegenerative diseases and other CNS disorders are nowadays considered some of the most challenging tasks in modern medicine. The development of effective strategies for the prevention, diagnosis and treatment of CNS pathologies require better understanding of neurological disorders that is still lacking. The use of nanomaterials is thought to contribute to our further understanding of the CNS and the development of novel therapeutic and diagnostic modalities for neurological interventions. Even though the application of nanoparticles in neuroscience is still embryonic, this article attempts to illustrate the use of different types of nanomaterials and the way in which they have been used in various CNS applications in an attempt to limit or reverse neuropathological processes.

摘要

治疗和诊断神经退行性疾病和其他中枢神经系统疾病目前被认为是现代医学中最具挑战性的任务之一。为预防、诊断和治疗中枢神经系统疾病制定有效策略需要更好地了解神经疾病,但目前这方面的认识仍然不足。纳米材料的使用被认为有助于我们进一步了解中枢神经系统,并为神经干预开发新的治疗和诊断方法。尽管纳米颗粒在神经科学中的应用仍处于起步阶段,但本文试图说明不同类型的纳米材料的用途,以及它们在各种中枢神经系统应用中的使用方式,试图限制或逆转神经病理过程。

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