Unidad para el Cuidado Integral de la Enfermedad Inflamatoria Intestinal Pediátrica, Sección de Gastroenterología, Hepatología y Nutrición Pediátrica, Hospital Sant Joan de Déu, Barcelona, Spain.
Inflamm Bowel Dis. 2013 Jan;19(1):73-80. doi: 10.1002/ibd.22980.
Although pediatric inflammatory bowel disease (IBD) diagnosis has increased in the last decades in Spain, there are no consistent epidemiologic data. Our aim was to describe the changing pattern of pediatric IBD incidence in Spain in the last 14 years.
A retrospective survey of patients diagnosed below 18 years of age in the period 1996-2009 was performed. Patients' data were obtained from the hospitals' databases. To avoid reduced accrual of cases diagnosed by adult physicians, adult IBD units in referral centers were invited to participate. Seventy-eight centers participated in our survey. Rates of incidence were calculated using age-stratified population-based epidemiologic data. Incidence rates were compared for the last 14 years (1996-2009).
In total, data from 2107 patients were obtained: 1,165 Crohn's disease (CD, 55.3%), 788 ulcerative colitis (UC, 37.4%), and 154 IBD unclassified. The sex distribution was 56.4% male, with higher predominance for CD (59.3%) as compared to UC (52.8%) and IBD unclassified (53.2%) (P = 0.012). The median age at diagnosis was 12.3 years (p25-75 9.7-14.6) with significant differences between diseases. IBD incidence increased from 0.97 to 2.8/100,000 inhabitants <18 years/year in the study period. Although this increase is more evident for CD (from 0.53 to 1.7), UC has also risen considerably (0.39 to 0.88).
This is the first attempt to calculate the current incidence of pediatric IBD in Spain. A significant increase of incidence rates in the study period was observed. In the last 14 years pediatric IBD incidence has almost tripled, with a more important CD increase.
尽管过去几十年来西班牙儿科炎症性肠病（IBD）的诊断有所增加，但目前仍缺乏一致的流行病学数据。我们的目的是描述过去 14 年来西班牙儿科 IBD 发病率的变化模式。
对 1996-2009 年期间诊断为 18 岁以下的患者进行回顾性调查。患者数据从医院数据库中获得。为了避免因成人医生诊断而导致病例数量减少，邀请了转诊中心的成人 IBD 单位参与调查。78 个中心参与了我们的调查。使用年龄分层的基于人群的流行病学数据计算发病率。比较了过去 14 年（1996-2009 年）的发病率。
共获得 2107 例患者的数据：1165 例克罗恩病（CD，55.3%），788 例溃疡性结肠炎（UC，37.4%）和 154 例 IBD 未分类。性别分布为 56.4%男性，CD 的比例明显高于 UC（59.3%比 52.8%）和 IBD 未分类（53.2%）（P=0.012）。诊断时的中位年龄为 12.3 岁（p25-75 为 9.7-14.6），不同疾病之间存在显著差异。在研究期间，IBD 的发病率从 0.97 增加到 2.8/100,000 名<18 岁/年。尽管 CD 的发病率增加更为明显（从 0.53 增加到 1.7），但 UC 的发病率也显著增加（从 0.39 增加到 0.88）。
这是首次尝试计算西班牙儿科 IBD 的当前发病率。在研究期间观察到发病率显著增加。在过去的 14 年中，儿科 IBD 的发病率几乎增加了两倍，其中 CD 的发病率增加更为显著。
