Stinski M F, Mocarski E S, Thomsen D R, Urbanowski M L
J Gen Virol. 1979 Apr;43(1):119-29. doi: 10.1099/0022-1317-43-1-119.
Early after infection of cells with cytomegalovirus, the membranes were modified with respect to both glycoprotein composition and immunological specificity. Virus-specified antigens were inserted into the plasma membrane at 24 h after infection, as much as 2 days before virion and dense body maturation. Although at least four virus-induced glycoproteins were synthesized and bound to plasma and microsomal membranes between 20 and 24 h after infection, virus-specified antigen accumulated primarily on the plasma membrane. In contrast, at late times (72 h) after infection when virus nucleocapsids can be detected in the necleus, virus-specified antigen was prominent on the plasma, endoplasmic reticulum and nuclear membranes. It is proposed that the virus-specified glycoproteins and antigens of this herpesvirus accumulate first on the plasma membrane and then on internal membranes. The appearance of virus-specified antigen on internal membranes coincides with the commencement of virion and dense body envelopment.
巨细胞病毒感染细胞后不久，细胞膜在糖蛋白组成和免疫特异性方面均发生了改变。病毒特异性抗原在感染后24小时插入质膜，比病毒粒子和致密体成熟提前多达2天。尽管在感染后20至24小时之间至少合成了四种病毒诱导的糖蛋白并与质膜和微粒体膜结合，但病毒特异性抗原主要积聚在质膜上。相反，在感染后期（72小时），当病毒核衣壳可在细胞核中检测到时，病毒特异性抗原在质膜、内质网和核膜上很突出。有人提出，这种疱疹病毒的病毒特异性糖蛋白和抗原首先在质膜上积累，然后在内膜上积累。内膜上病毒特异性抗原的出现与病毒粒子和致密体包膜的开始相吻合。
