Institute of Tropical Medicine, Department of Animal Health, Nationalestraat 155, B-2000 Antwerpen, Belgium.
Int J Parasitol. 2010 Apr;40(5):515-9. doi: 10.1016/j.ijpara.2010.01.006. Epub 2010 Feb 4.
A pilot field trial of the TSOL18 vaccine was undertaken in Cameroon. Two hundred and forty, 2-3 month-old piglets were distributed to 114 individual households in pairs. Vaccinated animals received three immunisations with 200 microg TSOL18 plus 5 mg Quil A and 30 mg/kg oxfendazole at the time of the second immunisation. Necropsies were undertaken when the pigs were approximately 12 months of age. Viable Taenia solium cysticerci were identified in 20 control pigs (prevalence 19.6%); no cysticerci were found in any of the vaccinated animals (P<0.0001). Combined application of TSOL18 vaccination and a single oxfendazole treatment in pigs may be a relatively simple and sustainable procedure that has the potential to control T. solium transmission in endemic areas and, indirectly, reduce the number of new cases of neurocysticercosis in humans.
在喀麦隆进行了 TSOL18 疫苗的初步实地试验。将 240 头 2-3 月龄的小猪分配给 114 个单独的农户，每对一头。接种疫苗的动物在第二次免疫时接受了 3 次免疫接种，每次接种 200 微克 TSOL18 加 5 毫克 Quil A 和 30 毫克/千克氧氟沙星。当这些猪大约 12 个月大时进行了剖检。在 20 头对照猪中发现了存活的猪囊尾蚴（患病率 19.6%）；在任何接种疫苗的动物中均未发现囊尾蚴（P<0.0001）。在猪中联合应用 TSOL18 疫苗接种和单次氧氟沙星治疗可能是一种相对简单和可持续的程序，有可能控制流行地区的猪带绦虫传播，并间接减少人类新的囊虫病病例。
