Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Diabetol Metab Syndr. 2012 May 2;4(1):18. doi: 10.1186/1758-5996-4-18.
The incidence of type 2 diabetes mellitus (T2DM) has been increasing in recent years. Sleep loss and circadian rhythm abnormalities are thought to be one of the underlying causes of adverse metabolic health. However, little is known about sleep-wake cycle irregularities in T2DM. The present study compared the bedtime, waking time, and estimated sleep duration between T2DM and non-T2DM subjects.
The study subjects were 106 consecutive outpatients with lifestyle-related diseases (males/females = 56/50), who answered a questionnaire on sleep status. Subjects were divided into two groups; non-T2DM (n = 32) and T2DM (n = 74) subjects.
T2DM subjects retired to bed on weekdays and holidays significantly later than non-T2DM subjects (23:43 versus 22:52, p = 0.0032; 23:45 versus 22:53, p = 0.0038, respectively), and woke up significantly later on weekdays and holidays, compared with non-T2DM subjects (06:39 versus 06:08, p = 0.0325; 06:58 versus 06:24, p = 0.0450, respectively). There was no significant difference in the estimated sleep duration between the two groups. Daytime sleepiness was reported significantly more commonly by T2DM subjects than non-T2DM subjects (p = 0.0195).
Sleep-wake cycle irregularities are more common in T2DM subjects than non-T2DM. Confirmation that such irregularity plays a role in the metabolic abnormalities of T2DM requires further investigation in the future.
UMIN 000002998.
近年来，2 型糖尿病（T2DM）的发病率一直在上升。睡眠不足和昼夜节律紊乱被认为是代谢健康不良的潜在原因之一。然而，关于 T2DM 患者睡眠-觉醒周期不规律的情况知之甚少。本研究比较了 T2DM 患者和非 T2DM 患者的就寝时间、醒来时间和估计睡眠时间。
本研究的受试者是 106 名连续的生活方式相关疾病门诊患者（男性/女性=56/50），他们回答了一份关于睡眠状况的问卷。受试者分为两组；非 T2DM（n=32）和 T2DM（n=74）组。
T2DM 患者工作日和节假日上床睡觉的时间明显晚于非 T2DM 患者（23:43 对 22:52，p=0.0032；23:45 对 22:53，p=0.0038），且工作日和节假日醒来的时间明显晚于非 T2DM 患者（06:39 对 06:08，p=0.0325；06:58 对 06:24，p=0.0450）。两组的估计睡眠时间无显著差异。T2DM 患者比非 T2DM 患者报告白天嗜睡的情况更为常见（p=0.0195）。
T2DM 患者的睡眠-觉醒周期不规律比非 T2DM 患者更为常见。未来需要进一步研究以确认这种不规律是否在 T2DM 的代谢异常中发挥作用。
UMIN 000002998。
