Liu Lei, Liu Li-Min, Hu Yue-Dong, Hua Rui, Chen Jun, Zhou Yun, Wan Chao, Huang Le-Le, Wu Jing-Yang, Geng Jin, Chen Lei
Department of Ophthalmology, the First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China.
Int J Ophthalmol. 2011;4(5):543-5. doi: 10.3980/j.issn.2222-3959.2011.05.16. Epub 2011 Oct 18.
To describe the design and preliminary results of the hospital based epidemiological study for diabetic retinopathy(HBESDR), an ongoing epidemiological study to estimate the prevalence of diabetic retinopathy(DR) and to elucidate the clinical, anthropometric, biochemical and any other risk factors associated with diabetic retinopathy.
Totally 2000 diabetes will be recruited from the Diabetes eye clinic in the First Affiliated Hospital of China Medical University. All subjects underwent blood sugar estimation and Oral Glucose Tolerance Test to diagnose diabetes. All diabetes would undergo complete questionnaire, a comprehensive eye examination. Blood and urine would be collected for biochemical investigations. All fundus photographs for any DR will be graded. Participants who need treatment will be sent to the ophthalmic clinic and follow-up interval program for all subjects will be suggested. A computerized database is created for the records.
To date, 1174 diabetes have been recruited, there were 350(29.81%) DR in all diabetes, most of them were with mild non-proliferative diabetic retinopathy (NPDR) (139, 39.71%); 71(20.29%) moderate NPDR, 66(18.86%) severe NPDR, 74(21.14%) proliferative diabetic retinopathy (PDR). Females, longer duration of diabetes, family history of diabetes and hypertension had a statistically significant increase in risk of any DR.
The study is expected to provide an estimate of the overall prevalence of DR and the prevalence with different duration of diabetes and also a better understanding of the risk factors associated with DR.
描述基于医院的糖尿病视网膜病变流行病学研究（HBESDR）的设计及初步结果，这是一项正在进行的流行病学研究，旨在估计糖尿病视网膜病变（DR）的患病率，并阐明与糖尿病视网膜病变相关的临床、人体测量学、生化及其他危险因素。
从中国医科大学附属第一医院糖尿病眼科门诊招募2000例糖尿病患者。所有受试者均进行血糖测定及口服葡萄糖耐量试验以诊断糖尿病。所有糖尿病患者均接受完整问卷调查、全面眼科检查。采集血液和尿液进行生化检查。所有糖尿病视网膜病变的眼底照片均进行分级。需要治疗的参与者将被送至眼科门诊，并为所有受试者建议随访间隔计划。建立计算机化数据库用于记录。
截至目前，已招募1174例糖尿病患者，所有糖尿病患者中糖尿病视网膜病变患者有350例（29.81%），其中大多数为轻度非增殖性糖尿病视网膜病变（NPDR）（139例，39.71%）；中度NPDR 71例（20.29%），重度NPDR 66例（18.86%），增殖性糖尿病视网膜病变（PDR）74例（21.14%）。女性、糖尿病病程较长、糖尿病家族史和高血压患者发生任何糖尿病视网膜病变的风险在统计学上显著增加。
该研究有望提供糖尿病视网膜病变的总体患病率估计以及不同糖尿病病程的患病率估计，并更好地了解与糖尿病视网膜病变相关的危险因素。
