Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Semin Cell Dev Biol. 2012 Sep;23(7):812-7. doi: 10.1016/j.semcdb.2012.04.006. Epub 2012 Apr 24.
Metazoan cells are exposed to a multitude of signals, which they integrate to determine appropriate developmental or physiological responses. Although the Hippo pathway was only discovered recently, and our knowledge of Hippo signal transduction is far from complete, a wealth of interconnections amongst Hippo and other signaling pathways have already been identified. Hippo signaling is particularly important for growth control, and I describe how integration of Hippo and other pathways contributes to regulation of organ growth. Molecular links between Hippo signaling and other signal transduction pathways are summarized. Different types of mechanisms for signal integration are described, and examples of how the complex interconnections between pathways are used to guide developmental and physiological growth responses are discussed. Features of Hippo signaling appear to make it particularly well suited to signal integration, including its responsiveness to cell-cell contact and the mediation of its transcriptional output by transcriptional co-activator proteins that can interact with transcription factors of other pathways.
后生动物细胞会受到多种信号的影响，它们会整合这些信号来确定适当的发育或生理反应。尽管 Hippo 途径是最近才被发现的，而且我们对 Hippo 信号转导的了解还远远不够，但 Hippo 与其他信号通路之间已经存在大量的相互联系。Hippo 信号对生长控制尤为重要，我将描述 Hippo 和其他途径的整合如何有助于调节器官生长。总结了 Hippo 信号与其他信号转导通路之间的分子联系。描述了不同类型的信号整合机制，并讨论了如何利用途径之间的复杂联系来指导发育和生理生长反应。Hippo 信号的特征似乎使其特别适合信号整合，包括其对细胞间接触的响应以及其转录输出由转录共激活蛋白介导，这些蛋白可以与其他途径的转录因子相互作用。
