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1
Production of plasminogen activator by human and hamster cells infected with human cytomegalovirus.人巨细胞病毒感染的人和仓鼠细胞产生纤溶酶原激活剂。
J Virol. 1979 Aug;31(2):415-9. doi: 10.1128/JVI.31.2.415-419.1979.
2
Production of plasminogen activator by cells transformed by herpesviruses.疱疹病毒转化细胞产生纤溶酶原激活物。
Cancer Res. 1978 Apr;38(4):1075-8.
3
Malignant transformation of hamster embryo fibroblasts following exposure to ultraviolet-irradiated human cytomegalovirus.暴露于紫外线照射的人巨细胞病毒后仓鼠胚胎成纤维细胞的恶性转化
Virology. 1973 Sep;55(1):53-61. doi: 10.1016/s0042-6822(73)81007-4.
4
Quantification of plasminogen activator activity associated with herpesvirus-transformed cells.与疱疹病毒转化细胞相关的纤溶酶原激活物活性的定量分析。
J Gen Virol. 1980 Sep;50(1):101-10. doi: 10.1099/0022-1317-50-1-101.
5
Induction of cellular DNA synthesis and increased mitotic activity in syrian hamster embryo cells abortively infected with human cytomegalovirus.人巨细胞病毒流产感染的叙利亚仓鼠胚胎细胞中细胞DNA合成的诱导及有丝分裂活性增加。
J Gen Virol. 1976 Feb;30(2):167-77. doi: 10.1099/0022-1317-30-2-167.
6
Reexamination of the role of plasminogen activator production for growth in semisolid agar of neoplastic hamster cells.
Cancer Res. 1980 May;40(5):1438-42.
7
Production of plasminogen activator by a primary HSV-2-induced hamster fibrosarcoma and its in vivo derived sublines.原发性单纯疱疹病毒2型诱导的仓鼠纤维肉瘤及其体内衍生亚系产生纤溶酶原激活物。
Cancer. 1986 Apr 15;57(8):1522-7. doi: 10.1002/1097-0142(19860415)57:8<1522::aid-cncr2820570814>3.0.co;2-o.
8
Plasminogen activator: induction of synthesis by DNA damage.纤溶酶原激活剂：DNA损伤诱导的合成
Cell. 1980 Jan;19(1):217-24. doi: 10.1016/0092-8674(80)90403-1.
9
Expression of early virus functions in human cytomegalovirus infected HEL cells: effect of ultraviolet light-irradiation of the virus.人巨细胞病毒感染的人胚肺成纤维细胞中早期病毒功能的表达：病毒紫外线照射的影响
J Gen Virol. 1978 Jan;38(1):121-33. doi: 10.1099/0022-1317-38-1-121.
10
Tumorigenicity of herpesvirus-transformed cells correlates with production of plasminogen activator.
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引用本文的文献

1
Human cytomegalovirus (strain AD169) contains sequences related to the avian retrovirus oncogene v-myc.
Proc Natl Acad Sci U S A. 1983 Jul;80(13):3889-93. doi: 10.1073/pnas.80.13.3889.
2
Actin distribution and synthesis in human fibroblasts infected by cytomegalovirus.巨细胞病毒感染的人成纤维细胞中肌动蛋白的分布与合成
Arch Virol. 1982;71(4):353-9. doi: 10.1007/BF01315066.
3
Dissociation between cellular DNA- and histone synthesis following infection by cytomegalovirus in the presence of phosphonoacetic acid.在膦甲酸存在的情况下，巨细胞病毒感染后细胞DNA合成与组蛋白合成之间的解离。
Arch Virol. 1981;68(3-4):313-20. doi: 10.1007/BF01314588.
4
Enhanced capacity of DNA repair in human cytomegalovirus-infected cells.人巨细胞病毒感染细胞中DNA修复能力增强。
J Virol. 1981 Apr;38(1):164-72. doi: 10.1128/JVI.38.1.164-172.1981.
5
Tumorigenicity of herpesvirus-transformed cells correlates with production of plasminogen activator.
Mol Cell Biol. 1981 May;1(5):408-17. doi: 10.1128/mcb.1.5.408-417.1981.
6
Human cytomegalovirus induces stage-specific embryonic antigen 1 in differentiating human teratocarcinoma cells and fibroblasts.人巨细胞病毒在分化的人畸胎瘤细胞和成纤维细胞中诱导阶段特异性胚胎抗原1。
J Exp Med. 1989 Apr 1;169(4):1347-59. doi: 10.1084/jem.169.4.1347.

本文引用的文献

1
Incorporation of 3H-uridine and 3H-uracil into RNA: a simple technique for the detection of mycoplasma contamination of cultured cells.将3H-尿苷和3H-尿嘧啶掺入RNA：一种检测培养细胞支原体污染的简单技术。
Exp Cell Res. 1974 Mar 15;84(1):311-8. doi: 10.1016/0014-4827(74)90411-x.
2
Fibrinolysis associated with oncogenic transformation. Partial purification and characterization of the cell factor, a plasminogen activator.与致癌转化相关的纤维蛋白溶解。细胞因子（一种纤溶酶原激活剂）的部分纯化及特性鉴定。
J Biol Chem. 1974 Jul 10;249(13):4295-305.
3
Fibrinolysis associated with oncogenic transformation. Morphological correlates.与致癌转化相关的纤维蛋白溶解。形态学关联。
J Biol Chem. 1974 Jul 10;249(13):4312-20.
4
Growth in agarose of human cells infected with cytomegalovirus.感染巨细胞病毒的人类细胞在琼脂糖中的生长情况。
J Virol. 1974 Aug;14(2):327-32. doi: 10.1128/JVI.14.2.327-332.1974.
5
Purification and characterization of a cellular fibrinolytic factor associated with oncogenic transformation: the plasminogen activator from SV-40-transformed hamster cells.与致癌转化相关的细胞纤溶因子的纯化与特性鉴定：来自SV - 40转化仓鼠细胞的纤溶酶原激活物
Biochim Biophys Acta. 1974 Mar 27;340(3):339-47. doi: 10.1016/0005-2787(74)90279-2.
6
Analysis of minimal functions of simian virus 40. 3. Evidence for "host cell repair" of oncogenicity and infectivity of UV-irradiated simian virus 40.猴病毒40最小功能的分析。3. 紫外线照射的猴病毒40致癌性和感染性“宿主细胞修复”的证据。
J Virol. 1974 Jan;13(1):36-41. doi: 10.1128/JVI.13.1.36-41.1974.
7
Malignant transformation of hamster embryo fibroblasts following exposure to ultraviolet-irradiated human cytomegalovirus.暴露于紫外线照射的人巨细胞病毒后仓鼠胚胎成纤维细胞的恶性转化
Virology. 1973 Sep;55(1):53-61. doi: 10.1016/s0042-6822(73)81007-4.
8
Growth characteristics of cytomegalovirus in human fibroblasts with demonstration of protein synthesis early in viral replication.人成纤维细胞中巨细胞病毒的生长特性及病毒复制早期蛋白质合成的证明
J Virol. 1973 Jun;11(6):991-7. doi: 10.1128/JVI.11.6.991-997.1973.
9
An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses.一种与致癌病毒转化成纤维细胞相关的酶功能。I. 禽RNA肿瘤病毒转化的鸡胚成纤维细胞培养物。
J Exp Med. 1973 Jan 1;137(1):85-111. doi: 10.1084/jem.137.1.85.
10
Plaque assay of cytomegalovirus strains of human origin.人源巨细胞病毒毒株的空斑试验
Proc Soc Exp Biol Med. 1970 Nov;135(2):253-8. doi: 10.3181/00379727-135-35031.

人巨细胞病毒感染的人和仓鼠细胞产生纤溶酶原激活剂。

Production of plasminogen activator by human and hamster cells infected with human cytomegalovirus.

作者信息

Yamanishi K, Rapp F

出版信息

J Virol. 1979 Aug;31(2):415-9. doi: 10.1128/JVI.31.2.415-419.1979.

DOI:10.1128/JVI.31.2.415-419.1979
PMID:225562
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC353464/
Abstract

Plasminogen activator was produced by both human embryo fibroblasts (a permissive system) and hamster embryo fibroblasts (a nonpermissive system) after exposure to human cytomegalovirus. The level of this activator was measured by using plates coated with [125I]fibrin. The production of plasminogen activator was enhanced when the human cells were exposed to human cytomegalovirus previously irradiated with UV light (5,520 to 55,200 ergs/mm2).

摘要

人胚胎成纤维细胞（一种允许系统）和仓鼠胚胎成纤维细胞（一种非允许系统）在暴露于人类巨细胞病毒后都会产生纤溶酶原激活物。通过使用包被有[125I]纤维蛋白的平板来测定这种激活物的水平。当人类细胞暴露于先前经紫外线照射（5520至55200尔格/平方毫米）的人类巨细胞病毒时，纤溶酶原激活物的产生会增强。