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Hair cortisol level as a biomarker for altered hypothalamic-pituitary-adrenal activity in female adolescents with posttraumatic stress disorder after the 2008 Wenchuan earthquake.创伤后应激障碍女性青少年在 2008 年汶川地震后的头发皮质醇水平作为下丘脑-垂体-肾上腺活动改变的生物标志物。
Biol Psychiatry. 2012 Jul 1;72(1):65-9. doi: 10.1016/j.biopsych.2011.12.020. Epub 2012 Feb 1.
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Effect of snack eating on sensitive salivary stress markers cortisol and chromogranin A.零食摄入对敏感唾液应激标志物皮质醇和嗜铬粒蛋白 A 的影响。
Environ Health Prev Med. 2004 Jan;9(1):27-9. doi: 10.1265/ehpm.9.27.
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A socio-relational framework of sex differences in the expression of emotion.社会关系框架下情绪表达的性别差异。
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Increased serum cortisol and growth hormone levels in earthquake survivors with PTSD or subclinical PTSD.创伤后应激障碍(PTSD)或亚临床PTSD的地震幸存者血清皮质醇和生长激素水平升高。
Psychoneuroendocrinology. 2008 Sep;33(8):1155-9. doi: 10.1016/j.psyneuen.2008.05.005. Epub 2008 Jul 21.
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Three-year follow-up study of the relationship between posttraumatic stress symptoms and quality of life among earthquake survivors in Yu-Chi, Taiwan.台湾鱼池地震幸存者创伤后应激症状与生活质量关系的三年随访研究
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One-year follow-up study of posttraumatic stress disorder among earthquake survivors in Turkey.土耳其地震幸存者创伤后应激障碍的一年随访研究
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东日本大地震的影响:创伤后应激、心理变化和幸存者的皮质醇水平。

Effects of the Higashi-Nihon earthquake: posttraumatic stress, psychological changes, and cortisol levels of survivors.

机构信息

Smart Ageing International Research Centre, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

出版信息

PLoS One. 2012;7(4):e34612. doi: 10.1371/journal.pone.0034612. Epub 2012 Apr 25.

DOI:10.1371/journal.pone.0034612
PMID:22558092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3338801/
Abstract

On March 11, 2011, the Pacific side of Japan's northeast was devastated by an earthquake and tsunami. For years, many researchers have been working on ways of examining the psychological effects of earthquakes on survivors in disaster areas who have experienced aftershocks, catastrophic fires, and other damage caused by the earthquake. The goal of this study is to examine scores on psychological measures and salivary cortisol level in these individuals both before and three months after the earthquake. The participants had been measured for these variables before the earthquake. After the earthquake, we carried out PTSD screening using CAPS for participants for another experiment, and then again conducted the aforementioned tests. We collected saliva samples from all survivors. Our results show that social relationship scores on the WHO-QOL26, negative mood scores of the WHO-SUBI, total GHQ score, POMS confusion scores, and CMI emotional status score after the earthquake showed scores indicating significantly decreased compared to before the earthquake. On the other hand, salivary cortisol levels after the earthquake was significantly increased compared to before the earthquake. Moreover, the result of a multiple regression analysis found that negative mood score on the WHO-SUBI and social relationship score on the WHO-QOL26 were significantly related to salivary cortisol levels. Our results thus demonstrate that several psychological stress induced by the earthquake was associated with an increase in salivary cortisol levels. These results show similar findings to previous study. We anticipate that this study will provide a better understanding of posttraumatic responses in the early stages of adaptation to the trauma and expand effective prevention strategies and countermeasures for PTSD.

摘要

2011 年 3 月 11 日,日本东北部太平洋一侧遭受地震和海啸的重创。多年来,许多研究人员一直在研究如何检查经历余震、灾难性火灾和地震造成的其他破坏的灾区幸存者的地震后的心理影响。本研究的目的是检查这些个体在地震前和三个月后心理测量得分和唾液皮质醇水平。参与者在地震前已经进行了这些变量的测量。地震后,我们使用 CAPS 对参与者进行 PTSD 筛查,然后再次进行上述测试。我们从所有幸存者中收集了唾液样本。我们的结果表明,WHO-QOL26 的社会关系得分、WHO-SUBI 的负面情绪得分、总 GHQ 得分、POMS 困惑得分和 CMI 情绪状态得分在地震后均显示出明显低于地震前的得分。另一方面,地震后的唾液皮质醇水平明显高于地震前。此外,多元回归分析的结果发现,WHO-SUBI 的负面情绪得分和 WHO-QOL26 的社会关系得分与唾液皮质醇水平显著相关。因此,我们的结果表明,地震引起的几种心理压力与唾液皮质醇水平的升高有关。这些结果与先前的研究结果相似。我们预计,这项研究将有助于更好地了解创伤适应早期的创伤后反应,并扩大 PTSD 的有效预防策略和对策。